| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; loading ...; fig 4a
| Gerber H, Mosser S, Boury Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:13 pubmed publisher |
- western blot; hamsters; fig 6b
- immunoprecipitation; mouse; fig 4d
- western blot; mouse; fig 4b
| Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher |
- western blot; human; fig 2
| Chhibber Goel J, Coleman Vaughan C, Agrawal V, Sawhney N, Hickey E, Powell J, et al. γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. J Biol Chem. 2016;291:5971-85 pubmed publisher |
- western blot; hamsters; fig 4
| Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero A, Dewachter I, et al. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem. 2015;290:7169-84 pubmed publisher |
- immunoprecipitation; human; 1:1000
- western blot; human
| Chen W, Hsieh Y, Huang Y, Lin C, Lin Y, Liu Y, et al. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. Mol Neurobiol. 2015;52:1835-1849 pubmed publisher |
| Poppe L, Rue L, Timmers M, Lenaerts A, Storm A, Callaerts Vegh Z, et al. EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2019;11:102 pubmed publisher |
| Kwart D, Gregg A, Scheckel C, Murphy E, Paquet D, Duffield M, et al. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ. Neuron. 2019;104:256-270.e5 pubmed publisher |
| Petit D, Hitzenberger M, Lismont S, Zoltowska K, Ryan N, Mercken M, et al. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. EMBO J. 2019;: pubmed publisher |
| Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed publisher |
| Chong C, Ke M, Tan Y, Huang Z, Zhang K, Ai N, et al. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing ?-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018;9:879 pubmed publisher |
| Hu J, Dziumbla S, Lin J, Bibli S, Zukunft S, de Mos J, et al. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 2017;552:248-252 pubmed publisher |
| Guix F, Sannerud R, Berditchevski F, Arranz A, Horré K, Snellinx A, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol Neurodegener. 2017;12:25 pubmed publisher |
| Li N, Liu K, Qiu Y, Ren Z, Dai R, Deng Y, et al. Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD. Front Aging Neurosci. 2016;8:51 pubmed publisher |
| Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, et al. The dynamic conformational landscape of gamma-secretase. J Cell Sci. 2015;128:589-98 pubmed |
| Fernandez M, Klutkowski J, Freret T, Wolfe M. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. J Biol Chem. 2014;289:31043-52 pubmed publisher |
| Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet. 2015;24:371-82 pubmed publisher |
| He P, Li P, Hua Q, Liu Y, Staufenbiel M, Li R, et al. Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e58181 pubmed publisher |
| Alattia J, Matasci M, Dimitrov M, Aeschbach L, Balasubramanian S, Hacker D, et al. Highly efficient production of the Alzheimer's ?-secretase integral membrane protease complex by a multi-gene stable integration approach. Biotechnol Bioeng. 2013;110:1995-2005 pubmed publisher |
| Alattia J, Schweizer C, Cacquevel M, Dimitrov M, Aeschbach L, Oulad Abdelghani M, et al. Generation of monoclonal antibody fragments binding the native ?-secretase complex for use in structural studies. Biochemistry. 2012;51:8779-90 pubmed publisher |
| Leroy K, Ando K, Laporte V, Dedecker R, Suain V, Authelet M, et al. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. Am J Pathol. 2012;181:1928-40 pubmed publisher |
| Cacquevel M, Aeschbach L, Houacine J, Fraering P. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified ?-secretase complexes. PLoS ONE. 2012;7:e35133 pubmed publisher |
| Chávez Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, et al. The mechanism of ?-Secretase dysfunction in familial Alzheimer disease. EMBO J. 2012;31:2261-74 pubmed publisher |
| Guix F, Wahle T, Vennekens K, Snellinx A, Chávez Gutiérrez L, Ill Raga G, et al. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012;4:660-73 pubmed publisher |
| Wang T, Wang C, Shan Z, Teng W, Wang Z. Clioquinol reduces zinc accumulation in neuritic plaques and inhibits the amyloidogenic pathway in A?PP/PS1 transgenic mouse brain. J Alzheimers Dis. 2012;29:549-59 pubmed publisher |
| Wang C, Zheng W, Wang T, Xie J, Wang S, Zhao B, et al. Huperzine A activates Wnt/?-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology. 2011;36:1073-89 pubmed publisher |
| Wang C, Wang T, Zheng W, Zhao B, Danscher G, Chen Y, et al. Zinc overload enhances APP cleavage and A? deposition in the Alzheimer mouse brain. PLoS ONE. 2010;5:e15349 pubmed publisher |
| Wu F, Schweizer C, Rudinskiy N, Taylor D, Kazantsev A, Luthi Carter R, et al. Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1. FASEB J. 2010;24:2464-74 pubmed publisher |
| Chen A, Guo L, Ostaszewski B, Selkoe D, LaVoie M. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem. 2010;285:11378-91 pubmed publisher |
| Oh S, Chen C, Abraham C. Cell-type dependent modulation of Notch signaling by the amyloid precursor protein. J Neurochem. 2010;113:262-74 pubmed publisher |
| Eckert G, Muller W. Presenilin 1 modifies lipid raft composition of neuronal membranes. Biochem Biophys Res Commun. 2009;382:673-7 pubmed publisher |
| Hemming M, Elias J, Gygi S, Selkoe D. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol. 2008;6:e257 pubmed publisher |
| Matsuda S, Giliberto L, Matsuda Y, McGowan E, D ADAMIO L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008;28:8668-76 pubmed publisher |
| Kienlen Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, et al. Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem. 2008;283:7733-44 pubmed publisher |
| Fuso A, Cavallaro R, Zampelli A, D Anselmi F, Piscopo P, Confaloni A, et al. gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis. 2007;11:275-90 pubmed |
| Shaughnessy L, Thomas M, Wakefield J, Chamblin B, Nair A, Koentgen F, et al. Lentiviral vector-based models of amyloid pathology: from cells to animals. Curr Alzheimer Res. 2005;2:239-47 pubmed |
