This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Macrophages/Monocytes Antibody, clone ED-1
catalog :
MAB1435
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ED-1
reactivity :
Styela clava, mouse, rat, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, radioimmunoassay, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 87
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; rat; 1:1000; loading ...; fig 3
Cha M, Lee K, Lee B. Astroglial changes in the zona incerta in response to motor cortex stimulation in a rat model of chronic neuropathy. Sci Rep. 2020;10:943 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
  • immunohistochemistry; rat; loading ...; fig 66
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 2a
Pang Y, Dai X, Roller A, Carter K, Paul I, Bhatt A, et al. Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats. PLoS ONE. 2016;11:e0164403 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 6g
Hu D, Zhu S, Potas J. Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury. J Neuroinflammation. 2016;13:200 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 5
Fischer K, Morgan K, Hearon K, Sklaviadis D, Tochka Z, Fenton O, et al. Poly(Limonene Thioether) Scaffold for Tissue Engineering. Adv Healthc Mater. 2016;5:813-21 pubmed publisher
  • immunohistochemistry; rat; fig 3
Ray S, Thormann U, Sommer U, Khassawna T, Hundgeburth M, Henß A, et al. Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats. Injury. 2016;47 Suppl 1:S52-61 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:300; fig 4
Niquet J, Gezalian M, Baldwin R, Wasterlain C. Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol. 2015;2:1105-15 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:300; loading ...; fig 6B
van Essen T, van Zijl L, Possemiers T, Mulder A, Zwart S, Chou C, et al. Biocompatibility of a fish scale-derived artificial cornea: Cytotoxicity, cellular adhesion and phenotype, and in vivo immunogenicity. Biomaterials. 2016;81:36-45 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 3
Watzlawik J, Kahoud R, Ng S, Painter M, Papke L, Zoecklein L, et al. Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015;134:865-78 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Potter Baker K, Ravikumar M, Burke A, Meador W, Householder K, Buck A, et al. A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models. Biomaterials. 2014;35:5637-46 pubmed publisher
  • immunohistochemistry; Styela clava; 1:100
Potter K, Jorfi M, Householder K, Foster E, Weder C, Capadona J. Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood-brain barrier stability. Acta Biomater. 2014;10:2209-22 pubmed publisher
  • immunohistochemistry; rat; 1:500
Mitchell K, Shah J, Tsytsikova L, Campbell A, Affram K, Symes A. LPS antagonism of TGF-? signaling results in prolonged survival and activation of rat primary microglia. J Neurochem. 2014;129:155-68 pubmed publisher
  • immunohistochemistry - paraffin section; pigs
Chow J, Simionescu D, Warner H, Wang B, Patnaik S, Liao J, et al. Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol. Biomaterials. 2013;34:685-95 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
Hsieh Y, Chou L, Chang P, Yang C, Kao M, Hong C. Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1? (HIF-1?). J Comp Neurol. 2012;520:2903-16 pubmed publisher
Manogaran P, Samardzija M, Schad A, Wicki C, Walker Egger C, Rudin M, et al. Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis. Acta Neuropathol Commun. 2019;7:116 pubmed publisher
Jeon H, Kim J, Choi J, Han E, Song C, Lee J, et al. Effects of the Extracts from Fruit and Stem of Camellia japonica on Induced Pluripotency and Wound Healing. J Clin Med. 2018;7: pubmed publisher
Zuo X, Hou Q, Jin J, Chen X, Zhan L, Tang Y, et al. Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats. Front Aging Neurosci. 2018;10:125 pubmed publisher
Son M, Lee M, Jeon H, Seol B, Kim J, Chang J, et al. Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease. Exp Mol Med. 2016;48:e232 pubmed publisher
Deep S, Baitharu I, Sharma A, Gurjar A, Prasad D, Singh S. Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour. PLoS ONE. 2016;11:e0153371 pubmed publisher
Li Y, Lein P, Ford G, Liu C, Stovall K, White T, et al. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation. 2015;12:64 pubmed publisher
Tosun C, Hong C, Carusillo B, Ivanova S, Gerzanich V, Simard J. Angiogenesis induced by prenatal ischemia predisposes to periventricular hemorrhage during postnatal mechanical ventilation. Pediatr Res. 2015;77:663-73 pubmed publisher
Zhan Y, Shi H, Caligiuri S, Wu Y, Declercq V, Taylor C, et al. Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy. J Nutr Biochem. 2015;26:130-7 pubmed publisher
Skardelly M, Gaber K, Burdack S, Scheidt F, Schuhmann M, Hilbig H, et al. Transient but not permanent benefit of neuronal progenitor cell therapy after traumatic brain injury: potential causes and translational consequences. Front Cell Neurosci. 2014;8:318 pubmed publisher
Hong J, Lee S, Lee S, Kim J, Kim K, Kim S, et al. Therapeutic potential of induced neural stem cells for spinal cord injury. J Biol Chem. 2014;289:32512-25 pubmed publisher
Alvarez M, Rivas L, Lacruz C, Toledano A. Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: a histological and immunohistochemical comparison. Glia. 2015;63:287-312 pubmed publisher
Blomstrand M, Kalm M, Grandér R, Bjork Eriksson T, Blomgren K. Different reactions to irradiation in the juvenile and adult hippocampus. Int J Radiat Biol. 2014;90:807-15 pubmed publisher
Kim H, Choi S, Yang W, Kim D, Lee D, Cho S, et al. PSA-NCAM(+) neural precursor cells from human embryonic stem cells promote neural tissue integrity and behavioral performance in a rat stroke model. Stem Cell Rev. 2014;10:761-71 pubmed publisher
Jin Y, Bouyer J, Haas C, Fischer I. Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat. Exp Neurol. 2014;257:57-69 pubmed publisher
Myers S, Andres K, Hagg T, Whittemore S. CD36 deletion improves recovery from spinal cord injury. Exp Neurol. 2014;256:25-38 pubmed publisher
Simard J, Pampori A, Keledjian K, Tosun C, Schwartzbauer G, Ivanova S, et al. Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the brain. J Neurotrauma. 2014;31:1292-304 pubmed publisher
Forrest S, Osborne P, Keast J. Characterization of bladder sensory neurons in the context of myelination, receptors for pain modulators, and acute responses to bladder inflammation. Front Neurosci. 2013;7:206 pubmed publisher
Barbe M, Gallagher S, Massicotte V, Tytell M, Popoff S, Barr Gillespie A. The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders. BMC Musculoskelet Disord. 2013;14:303 pubmed publisher
Sugiyama T, Lee S, Horie T, Oku H, Takai S, Tanioka H, et al. P2X? receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats. Mol Vis. 2013;19:2080-91 pubmed
Myers F, Silver J, Zhuge Y, Beygui R, Zarins C, Lee L, et al. Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning. Integr Biol (Camb). 2013;5:1495-506 pubmed publisher
Godinho M, Teh L, Pollett M, Goodman D, Hodgetts S, Sweetman I, et al. Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3. PLoS ONE. 2013;8:e69987 pubmed publisher
Yao L, Daly W, Newland B, Yao S, Wang W, Chen B, et al. Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene. Gene Ther. 2013;20:1149-57 pubmed publisher
Potter K, Buck A, Self W, Callanan M, Sunil S, Capadona J. The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes. Biomaterials. 2013;34:7001-15 pubmed publisher
White T, Ford G, Surles Zeigler M, Gates A, LaPlaca M, Ford B. Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. BMC Genomics. 2013;14:282 pubmed publisher
Pertici V, Amendola J, Laurin J, Gigmes D, Madaschi L, Carelli S, et al. The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination. ASN Neuro. 2013;5:149-66 pubmed publisher
Watzlawik J, Warrington A, Rodriguez M. PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation. PLoS ONE. 2013;8:e55149 pubmed publisher
Prasad A, Xue Q, Sankar V, Nishida T, Shaw G, Streit W, et al. Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants. J Neural Eng. 2012;9:056015 pubmed
Potter K, Buck A, Self W, Capadona J. Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses. J Neural Eng. 2012;9:046020 pubmed publisher
Lu Y, Tao R, Huang J, Li L, Liao M, Li X, et al. P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand. J Neuroinflammation. 2012;9:172 pubmed publisher
Simard J, Tosun C, Ivanova S, Kurland D, Hong C, Radecki L, et al. Heparin reduces neuroinflammation and transsynaptic neuronal apoptosis in a model of subarachnoid hemorrhage. Transl Stroke Res. 2012;3:155-65 pubmed publisher
Qin D, Morita H, Inui K, Tayama H, Inoue Y, Yoshimura A. Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. J Nephrol. 2013;26:199-206 pubmed publisher
Harkness L, Kassem M. Procedures for derivation and characterisation of human embryonic stem cells from Odense, Denmark. Methods Mol Biol. 2012;873:33-51 pubmed publisher
Lee J, Kim H, Choi H, Oh T, Ju B, Yune T. Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury. J Neurochem. 2012;121:818-29 pubmed publisher
Shimizu H, Bolati D, Higashiyama Y, Nishijima F, Shimizu K, Niwa T. Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-?B, p53, ERK, and JNK in proximal tubular cells. Life Sci. 2012;90:525-30 pubmed publisher
Prasad A, Sankar V, Dyer A, Knott E, Xue Q, Nishida T, et al. Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3020-3 pubmed publisher
Harris J, Capadona J, Miller R, Healy B, Shanmuganathan K, Rowan S, et al. Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies. J Neural Eng. 2011;8:066011 pubmed publisher
Mantopoulos D, Murakami Y, Comander J, Thanos A, Roh M, Miller J, et al. Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. PLoS ONE. 2011;6:e24245 pubmed publisher
Suzuki Y, Imada T, Yamaguchi I, Yoshitake H, Sanada H, Kashiwagi T, et al. Effects of prolonged water washing of tissue samples fixed in formalin on histological staining. Biotech Histochem. 2012;87:241-8 pubmed publisher
Bianchi M, Calvo V, Chasseing N, Lago N, Libertun C, Montaner A, et al. Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin-induced diabetes. Diabetes Metab Res Rev. 2012;28:156-63 pubmed publisher
Scotland P, Patil M, Belugin S, Henry M, Goffin V, Hargreaves K, et al. Endogenous prolactin generated during peripheral inflammation contributes to thermal hyperalgesia. Eur J Neurosci. 2011;34:745-54 pubmed publisher
Andersson H, Anderson M, Porritt M, Nodin C, Blomstrand F, Nilsson M. Trauma-induced reactive gliosis is reduced after treatment with octanol and carbenoxolone. Neurol Res. 2011;33:614-24 pubmed publisher
Brochu M, Girard S, Lavoie K, Sebire G. Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. J Neuroinflammation. 2011;8:55 pubmed publisher
Tu Y, Tsai Y, Wang L, Wu H, Huang C, Ho C. Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation. J Neuroinflammation. 2011;8:40 pubmed publisher
Li Y, Lein P, Liu C, Bruun D, Tewolde T, Ford G, et al. Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicol Appl Pharmacol. 2011;253:261-9 pubmed publisher
Muñoz Ortega M, Quintanar Stephano A, Garcia Lorenzana M, Campos Esparza M, Silva Briano M, Adabache Ortíz A, et al. Modulation of amoebic hepatic abscess by the parasympathetic system. Parasite Immunol. 2011;33:65-72 pubmed
Yamashita J, Koi K, Yang D, McCauley L. Effect of zoledronate on oral wound healing in rats. Clin Cancer Res. 2011;17:1405-14 pubmed publisher
Zhang H, Qiao H, Bakken A, Gao F, Huang B, Liu Y, et al. Utility of dual-modality bioluminescence and MRI in monitoring stem cell survival and impact on post myocardial infarct remodeling. Acad Radiol. 2011;18:3-12 pubmed publisher
Jokic N, Yip P, Michael Titus A, Priestley J, Malaspina A. The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression. BMC Genomics. 2010;11:633 pubmed publisher
Toblli J, Cao G, Giani J, Angerosa M, Dominici F, Gonzalez Cadavid N. Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis. Kidney Blood Press Res. 2011;34:20-33 pubmed publisher
Ogborn M, Nitschmann E, Bankovic Calic N, Weiler H, Aukema H. Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet. Exp Biol Med (Maywood). 2010;235:1315-20 pubmed publisher
Baumann M, Kang C, Tator C, Shoichet M. Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury. Biomaterials. 2010;31:7631-9 pubmed publisher
Kitani H, Takenouchi T, Sato M, Yoshioka M, Yamanaka N. A novel isolation method for macrophage-like cells from mixed primary cultures of adult rat liver cells. J Immunol Methods. 2010;360:47-55 pubmed publisher
Xue Q, Yang C, Hoffman P, Streit W. Microglial response to murine leukemia virus-induced encephalopathy is a good indicator of neuronal perturbations. Brain Res. 2010;1319:131-41 pubmed publisher
Sartori Valinotti J, Venegas Pont M, LaMarca B, Romero D, Yanes L, Racusen L, et al. Rosiglitazone reduces blood pressure in female Dahl salt-sensitive rats. Steroids. 2010;75:794-9 pubmed publisher
Busch S, Horn K, Silver D, Silver J. Overcoming macrophage-mediated axonal dieback following CNS injury. J Neurosci. 2009;29:9967-76 pubmed publisher
Joly S, Francke M, Ulbricht E, Beck S, Seeliger M, Hirrlinger P, et al. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol. 2009;174:2310-23 pubmed publisher
Biosse Duplan M, Baroukh B, Dy M, de Vernejoul M, Saffar J. Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol. 2009;174:1426-34 pubmed publisher
Hicks A, Lappalainen R, Narkilahti S, Suuronen R, Corbett D, Sivenius J, et al. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery. Eur J Neurosci. 2009;29:562-74 pubmed publisher
Kalm M, Lannering B, Bjork Eriksson T, Blomgren K. Irradiation-induced loss of microglia in the young brain. J Neuroimmunol. 2009;206:70-5 pubmed publisher
Zeis T, Kinter J, Herrero Herranz E, Weissert R, Schaeren Wiemers N. Gene expression analysis of normal appearing brain tissue in an animal model for multiple sclerosis revealed grey matter alterations, but only minor white matter changes. J Neuroimmunol. 2008;205:10-9 pubmed publisher
Ogborn M, Nitschmann E, Goldberg A, Bankovic Calic N, Weiler H, Aukema H. Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease. Lipids. 2008;43:783-91 pubmed publisher
Ronsyn M, Daans J, Spaepen G, Chatterjee S, Vermeulen K, D Haese P, et al. Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord. BMC Biotechnol. 2007;7:90 pubmed
Chirino Y, Trujillo J, Sánchez González D, Martínez Martínez C, Cruz C, Bobadilla N, et al. Selective iNOS inhibition reduces renal damage induced by cisplatin. Toxicol Lett. 2008;176:48-57 pubmed
Dominguez J, Wu P, Packer C, Temm C, Kelly K. Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy. Am J Physiol Renal Physiol. 2007;293:F670-9 pubmed
Ogborn M, Nitschmann E, Bankovic Calic N, Weiler H, Aukema H. Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender. Lipids. 2006;41:1141-9 pubmed
Kelsen J, Kjaer K, Chen G, Pedersen M, Røhl L, Frøkiaer J, et al. Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?. J Neuroinflammation. 2006;3:31 pubmed
Guo C, Martinez Vasquez D, Mendez G, Toniolo M, Yao T, Oestreicher E, et al. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology. 2006;147:5363-73 pubmed
Dominguez J, Wu P, Hawes J, Deeg M, Walsh J, Packer S, et al. Renal injury: similarities and differences in male and female rats with the metabolic syndrome. Kidney Int. 2006;69:1969-76 pubmed
Lee J, Basalyga D, Simionescu A, Isenburg J, Simionescu D, Vyavahare N. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006;168:490-8 pubmed
Ohlsson M, Hoang T, Wu J, Havton L. Glial reactions in a rodent cauda equina injury and repair model. Exp Brain Res. 2006;170:52-60 pubmed
Fouilloux I, Duplan M, Baroukh B, Cherruau M, Saffar J, Lesclous P. Mast cell activation and degranulation occur early during induction of periosteal bone resorption. Bone. 2006;38:59-66 pubmed
Al Shatti T, Barr A, Safadi F, Amin M, Barbe M. Increase in inflammatory cytokines in median nerves in a rat model of repetitive motion injury. J Neuroimmunol. 2005;167:13-22 pubmed
Zhang W, Chen X, Shi S, Wei R, Wang J, Yamanaka N, et al. Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. Nephrol Dial Transplant. 2005;20:892-901 pubmed
product information
Catalog Number :
MAB1435
Subcategory :
Inflammation & Immunology
Product Name :
Anti-Macrophages/Monocytes Antibody, clone ED-1
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Host Name :
Mouse
Antigen :
Macrophages/Monocytes
Clone :
ED-1
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Macrophages/Monocytes Antibody, clone ED-1
Cross Reactivity :
Rat
Background :
Monocytes are produced by the bone marrow from haematopoietic stem cell precursors called monoblasts. Monocytes circulate in the bloodstream for about one to three days and then typically move into tissues throughout the body. They consist of between 3 to 8 percent of the leukocytes in the blood. In the tissues monocytes mature into different types of macrophages at different anatomical locations. Macrophages are a type of white blood cell derived from monocytes that engulf invading antigenic molecules, viruses, and microorganisms and then display fragments of the antigen to activate helper T cells; ultimately stimulating the production of antibodies against the antigen.
Immunogen :
Rat spleen cells
Specificity :
Recognizes a single chain glycoprotein of 90-100 kD that is expressed on the lysomal membrane of myeloid cells. Weak cell surface expression also occurs. The antigen is expressed by the majority of tissue macrophages and weakly by peripheral blood granulocytes. Studies have shown that the antigen has many characteristics in common with macrosialin in the mouse and CD68 in the human. Clone ED1, which recognises a CD68 like molecule in rat is an excellent marker of activated microglia. For pan microglial markers, staining both resting and activated microglia, use like CD11b (MAB1387Z and others) or iba-1 (MABN92).
Package Size :
100 μg
Uses :
Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Radioimmunoassay;Western Blotting
Storage :
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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