Macrophages/Granulocytes Antibody, clone OX-41 | EMD Millipore MAB1407P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Macrophages/Granulocytes Antibody, clone OX-41

catalog :

MAB1407P

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OX-41

The same clone is also sold as:

LifeSpan Biosciences: LS-C45051, LS-C45052, LS-C96394, LS-C45053
BioLegend: 204706, 204702
Novus Biologicals: NB100-65530-250ug

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; fig 2	Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Goshima Y, et al. Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. Sci Rep. 2015;5:8269 pubmed publisher
	Yamagishi R, Aihara M. Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis. Mol Vis. 2014;20:1796-805 pubmed
	Zhang X, Li Liu D, Chiang S, Choy K, Pang C, Lam D, et al. Immunopanning purification and long-term culture of human retinal ganglion cells. Mol Vis. 2010;16:2867-72 pubmed
	Kitani H, Takenouchi T, Sato M, Yoshioka M, Yamanaka N. A novel isolation method for macrophage-like cells from mixed primary cultures of adult rat liver cells. J Immunol Methods. 2010;360:47-55 pubmed publisher
	Lee K, Nakayama M, Aihara M, Chen Y, Araie M. Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress, and hypoxia in purified rat retinal ganglion cells. Mol Vis. 2010;16:246-51 pubmed
	Yu Z, Chen Y, Aihara M, Mao W, Uchida S, Araie M. Effects of beta-adrenergic receptor antagonists on oxidative stress in purified rat retinal ganglion cells. Mol Vis. 2007;13:833-9 pubmed

product information

Catalog Number :

MAB1407P

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Macrophages/Granulocytes Antibody, clone OX-41

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P78324

Host Name :

Mouse

Antigen :

Macrophages/Granulocytes

Clone :

OX-41

Conjugate :

Affinity Purified

Isotype :

IgG2a

Product Description :

Anti-Macrophages/Granulocytes Antibody, clone OX-41

Cross Reactivity :

Human;Mouse;Rat

Background :

Macrophages and granulocytes express Signal regulatory protein (SIRP), which is a transmembrane glycoprotein involved in the down regulation of tyrosine kinase receptor signal transduction induced by cell adhesion, growth factors or insulin. They are immunoglobulin-like cell surface receptor for CD47. By CD47 binding there is a negative regulation of phagocytosis, mast cell activation and dendritic cell activation that prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

ALT Names :

CD172 antigen-like family member A;CD172a antigen;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen;SHP substrate 1;SHP substrate-1;Signal-regulatory protein alpha-1;signal-regulatory protein alpha

Immunogen :

Rat peritoneal macrophages.

Specificity :

MAB1407P recognizes rat SIRP (Signal regulatory protein), which is expressed selectively by myeloid cells and by neurons. This monoclonal binds to a different epitope on SIRP than ED9. It does not block the interaction of CD172a and CD47. Labels most macrophages including resident peritoneal, alveolar and activated macrophages. Recognition of other macrophages is limited to only occasional kupffer cells. In addition it labels granulocytes and a population of dendritic cells. It also labels brain extensively.

Package Size :

100 µg

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.