Integrin α4 Antibody, clone HP2/1 | EMD Millipore MAB1383 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin α4 Antibody, clone HP2/1

catalog :

MAB1383

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HP2/1

The same clone is also sold as:

LifeSpan Biosciences: LS-C45276, LS-C85009
Invitrogen: MA1-80529
Abcam: ab22858
OriGene: SM2198P, SM2198PS
Bio-Rad: MCA697, MCA697GA
Beckman Coulter: B01682, IM0764, IM1404U

reactivity :

human, rat

application :

immunohistochemistry, immunoprecipitation, flow cytometry

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig s6	HÃ¸ye A, Couchman J, Wewer U, Yoneda A. The Phosphorylation and Distribution of Cortactin Downstream of Integrin Î±9Î²1 Affects Cancer Cell Behaviour. Sci Rep. 2016;6:28529 pubmed publisher
	Hui T, SÃ¸rensen E, Rittling S. Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin. Matrix Biol. 2015;41:19-25 pubmed publisher
	Teo G, Ankrum J, Martinelli R, Boetto S, Simms K, Sciuto T, et al. Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-?-activated endothelial cells via both leukocyte-like and novel mechanisms. Stem Cells. 2012;30:2472-86 pubmed publisher
	Walsh E, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, et al. Importance of interaction between nerve growth factor and ?9?1 integrin in glial tumor angiogenesis. Neuro Oncol. 2012;14:890-901 pubmed publisher
	Lawson C, Lim S, Uryu S, Chen X, Calderwood D, Schlaepfer D. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol. 2012;196:223-32 pubmed publisher
	Li H, Pauza C. HIV envelope-mediated, CCR5/?4?7-dependent killing of CD4-negative ?? T cells which are lost during progression to AIDS. Blood. 2011;118:5824-31 pubmed publisher
	Darc M, Hait S, Soares E, Cicala C, Seuanez H, Machado E, et al. Polymorphisms in the ?4 integrin of neotropical primates: insights for binding of natural ligands and HIV-1 gp120 to the human ?4?7. PLoS ONE. 2011;6:e24461 pubmed publisher
	Faralli J, Newman J, Sheibani N, Dedhar S, Peters D. Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011;52:1684-92 pubmed publisher
	Westhorpe C, Zhou J, Webster N, Kalionis B, Lewin S, Jaworowski A, et al. Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages. J Leukoc Biol. 2009;85:1027-35 pubmed publisher
	Slack Davis J, Atkins K, Harrer C, Hershey E, Conaway M. Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res. 2009;69:1469-76 pubmed publisher
	Fiorilli P, Partridge D, Staniszewska I, Wang J, Grabacka M, So K, et al. Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation. Lab Invest. 2008;88:1143-56 pubmed publisher
	Kanda H, Newton R, Klein R, Morita Y, Gunn M, Rosen S. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol. 2008;9:415-23 pubmed publisher
	Wu L, Bernard Trifilo J, Lim Y, Lim S, Mitra S, Uryu S, et al. Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene. 2008;27:1439-48 pubmed

product information

Catalog Number :

MAB1383

Subcategory :

Cell Structure

Product Name :

Anti-Integrin α4 Antibody, clone HP2/1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P13612

Host Name :

Mouse

Antigen :

Integrin α4

Clone :

HP2/1

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Integrin α4 Antibody, clone HP2/1

Cross Reactivity :

Bovine;Human;Rat

ALT Names :

CD49d

Immunogen :

JM leukemia line

Specificity :

Recognizes the 80kDa alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1.

Package Size :

100 µg

Uses :

Flow Cytometry;Immunoprecipitation;Immunohistochemistry

Storage :

Store at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.