Integrin α6A Antibody, cytoplasmic domain, clone 1A10 | EMD Millipore MAB1356 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin α6A Antibody, cytoplasmic domain, clone 1A10

catalog :

MAB1356

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A10

The same clone is also sold as:

Santa Cruz Biotechnology: sc-59970

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 6

Reference
Rasini V, Dominici M, Kluba T, Siegel G, Lusenti G, Northoff H, et al. Mesenchymal stromal/stem cells markers in the human bone marrow. Cytotherapy. 2013;15:292-306 pubmed publisher
Scales T, Jayo A, Obara B, Holt M, Hotchin N, Berditchevski F, et al. ?3?1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments. Oncogene. 2013;32:3965-79 pubmed publisher
Qu H, Wen T, Pesch M, Aumailley M. Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes. Am J Pathol. 2012;180:1581-92 pubmed publisher
Ohara T, Kawashiri S, Tanaka A, Noguchi N, Kitahara H, Okamune A, et al. Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma. Pathol Oncol Res. 2009;15:429-36 pubmed publisher
Lombaert I, Brunsting J, Wierenga P, Faber H, Stokman M, Kok T, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE. 2008;3:e2063 pubmed publisher
Ling T, Kuo M, Li C, Yu A, Huang Y, Wu T, et al. Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Proc Natl Acad Sci U S A. 2006;103:9530-5 pubmed

product information

Catalog Number :

MAB1356

Subcategory :

Cell Structure

Product Name :

Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P23229

Host Name :

Mouse

Antigen :

Integrin α6A

Clone :

1A10

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

Cross Reactivity :

Human

Background :

Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.

ALT Names :

CD49f

Immunogen :

Synthetic peptide corresponding to the cytoplasmic C-terminal 28 amino acids including an appending N-terminal cysteine:CKKDHYDATYHKAEIHAQPSDKERLTSDA.

Specificity :

MAB1356 reacts exclusively with the cytoplasmic domain of non-phosphorylated integrin subunit alpha 6A. The antibody stains the basement membrane zone of skin, myoepithelial cells in sweat glands, peripheral nerves, sebaceous glands and some blood vessels in the dermis. Brroad species reactivity is expected because of the conserved nature of the epitope.

Package Size :

100 µg

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Maintain at 2-8°C for 3-4 weeks or long term at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.