TIMP-2 Antibody, clone 2TMP05 | EMD Millipore MAB13446 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TIMP-2 Antibody, clone 2TMP05

catalog :

MAB13446

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2TMP05

reactivity :

human, mouse, rat, Xenopus laevis

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; Xenopus laevis; fig 1	Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed publisher
immunohistochemistry - frozen section; rat	Guerra C, Carla Lara Pereira Y, Issa J, Luiz K, Guimarães E, Gerlach R, et al. Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats. Biomed Res Int. 2014;2014:563463 pubmed publisher
western blot; rat	Kopaliani I, Martin M, Zatschler B, Bortlik K, Müller B, Deussen A. Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Res Cardiol. 2014;109:419 pubmed publisher
	Ceron C, Rizzi E, Guimaraes D, Martins Oliveira A, Cau S, Ramos J, et al. Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension. Matrix Biol. 2012;31:261-70 pubmed publisher
	Louboutin J, Reyes B, Agrawal L, Van Bockstaele E, Strayer D. HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy. Eur J Neurosci. 2011;34:2015-23 pubmed publisher
	Solini A, Rossi C, Santini E, Madec S, Salvati A, Ferrannini E. Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation. J Hypertens. 2011;29:1930-9 pubmed publisher
	Sen E, Balikoglu Yilmaz M, Bozdag Pehlivan S, Sungu N, Aksakal F, Altinok A, et al. Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model. J Ocul Pharmacol Ther. 2010;26:399-406 pubmed publisher
	Madec S, Chiarugi M, Santini E, Rossi C, Miccoli P, Ferrannini E, et al. Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients. J Hypertens. 2010;28:1459-65 pubmed
	Castro M, Rizzi E, Prado C, Rossi M, Tanus Santos J, Gerlach R. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling. Matrix Biol. 2010;29:194-201 pubmed publisher
	Castro M, Rizzi E, Rodrigues G, Ceron C, Bendhack L, Gerlach R, et al. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med. 2009;46:1298-307 pubmed publisher
	Visigalli D, Palmieri D, Strangio A, Astigiano S, Barbieri O, Casartelli G, et al. The carboxyl terminal trimer of procollagen I induces pro-metastatic changes and vascularization in breast cancer cells xenografts. BMC Cancer. 2009;9:59 pubmed publisher

product information

Catalog Number :

MAB13446

Subcategory :

Cell Structure

Product Name :

Anti-TIMP-2 Antibody, clone 2TMP05

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16035

Host Name :

Mouse

Antigen :

TIMP-2

Clone :

2TMP05

Conjugate :

Purified

Product Description :

Anti-TIMP-2 Antibody, clone 2TMP05

Cross Reactivity :

Bovine;Guinea Pig;Human;Mouse;Rat;Rabbit

ALT Names :

Tissue Inhibitor of Metalloproteinase-2

Immunogen :

A synthetic peptide from the N-terminal region of human TIMP-2 protein.

Specificity :

MAB13446 recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. CHEMICON MAB13446 may be used to evaluate the invasive nature of some tumor types and determine the tissue distribution of TIMPs in other tumors such as adenomas and also its normal tissue. CELLULAR LOCALIZATION: Cytoplasmic

Package Size :

100 µg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Antibody with sodium azide is stable for 12 months after date of receipt when stored at 2-8°C.