MMP-2 Antibody, pro and active form, clone A-Gel VC2 | EMD Millipore MAB13431 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-2 Antibody, pro and active form, clone A-Gel VC2

catalog :

MAB13431

quantity :

500 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A-Gel VC2

The same clone is also sold as:

LifeSpan Biosciences: LS-C88487, LS-C88486, LS-C88488

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50	Perek B, Malinska A, Misterski M, Ostalska Nowicka D, Zabel M, Perek A, et al. Preexisting high expression of matrix metalloproteinase-2 in tunica media of saphenous vein conduits is associated with unfavorable long-term outcomes after coronary artery bypass grafting. Biomed Res Int. 2013;2013:730721 pubmed publisher
	Gai J, Wahafu W, Song L, Ping H, Wang M, Yang F, et al. Expression of CD74 in bladder cancer and its suppression in association with cancer proliferation, invasion and angiogenesis in HT-1376 cells. Oncol Lett. 2018;15:7631-7638 pubmed publisher
	Marano G, Gronewold C, Frank M, Merling A, Kliem C, Sauer S, et al. An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells. Beilstein J Org Chem. 2012;8:787-803 pubmed
	Wittschieber D, Stenzinger A, Klauschen F, Stephan C, Jung K, Erbersdobler A, et al. Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness. Pathobiology. 2011;78:123-31 pubmed publisher
	Brejchova K, Liskova P, Cejkova J, Jirsova K. Role of matrix metalloproteinases in recurrent corneal melting. Exp Eye Res. 2010;90:583-90 pubmed publisher
	Brejchova K, Liskova P, Hrdlickova E, Filipec M, Jirsova K. Matrix metalloproteinases in recurrent corneal melting associated with primary Sjörgen's syndrome. Mol Vis. 2009;15:2364-72 pubmed
	Leinonen T, Pirinen R, Böhm J, Johansson R, Kosma V. Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer. Histol Histopathol. 2008;23:693-700 pubmed publisher
	Frey A, Wali A, Pass H, Lonardo F. Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma. Histopathology. 2007;50:720-6 pubmed
	Díaz Sánchez M, Williams K, DeLuca G, Esiri M. Protein co-expression with axonal injury in multiple sclerosis plaques. Acta Neuropathol. 2006;111:289-99 pubmed

product information

Catalog Number :

MAB13431

Subcategory :

Cell Structure

Product Name :

Anti-MMP-2 Antibody, pro and active form, clone A-Gel VC2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08253

Host Name :

Mouse

Antigen :

MMP-2

Clone :

A-Gel VC2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-2 Antibody, pro and active form, clone A-Gel VC2

Cross Reactivity :

Human

Background :

MMPs have a common mode of activation, a conserved amino acid sequence in the putative metal-binding active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). These MMPs and TIMPs could be expressed by either the cancer or the stromal cells. There is a cooperation between tumor and stromal cells, in particular for the production of 72-kD type IV collagenase, involved in the disruption of basement membranes. A lack of TIMP-1 expression from invasive cancer cells could also contribute to matrix destruction.

ALT Names :

Gelatinase A; 72 kDa Type IV Collagenase

Immunogen :

Human APMA-activated native 72kDa Gelatinase A.

Specificity :

MAB13431 recognizes proteins of 72kDa and ~66kDa which are identified as pro (latent) and active forms of matrix metalloproteinase-2 (MMP-2; also known as 72kDa collagenase IV or gelatinase A). CHEMICON MAB-13431 shows no cross-reaction with pro and active forms of other MMPs. CELLULAR LOCALIZATION: Cytoplasmic.

Package Size :

500 µL

Uses :

ELISA;Immunohistochemistry;Immunohistochemistry (Paraffin)

Storage :

Antibody is stable for 12 months when stored at 2-8 C