MMP-13 Antibody, clone VIIIA2 | EMD Millipore MAB13424 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-13 Antibody, clone VIIIA2

catalog :

MAB13424

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VIIIA2

The same clone is also sold as:

Novus Biologicals: NB110-5919
Invitrogen: MA5-14238

reactivity :

human, mouse, rhesus macaque

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; rhesus macaque; 1:200	Liang R, Zong W, Palcsey S, Abramowitch S, Moalli P. Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque. Am J Obstet Gynecol. 2015;212:174.e1-7 pubmed publisher
immunohistochemistry - frozen section; mouse western blot; mouse	Kim B, Abdel Rahman M, Wang T, Pouly S, Mahmoud A, Cebulla C. Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment. Invest Ophthalmol Vis Sci. 2014;55:2031-40 pubmed publisher
immunohistochemistry - paraffin section; human; 5 ug/ml	Nkyimbeng T, Ruppert C, Shiomi T, Dahal B, Lang G, Seeger W, et al. Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis. PLoS ONE. 2013;8:e73279 pubmed publisher
immunohistochemistry - paraffin section; mouse	Ruan M, Erez A, Guse K, Dawson B, Bertin T, Chen Y, et al. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med. 2013;5:176ra34 pubmed publisher
	Nakamura D, Hollander J, Uchimura T, Nielsen H, Zeng L. Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskelet Disord. 2017;18:39 pubmed publisher
	Brejchova K, Liskova P, Cejkova J, Jirsova K. Role of matrix metalloproteinases in recurrent corneal melting. Exp Eye Res. 2010;90:583-90 pubmed publisher
	Brejchova K, Liskova P, Hrdlickova E, Filipec M, Jirsova K. Matrix metalloproteinases in recurrent corneal melting associated with primary Sjörgen's syndrome. Mol Vis. 2009;15:2364-72 pubmed
	Lausch E, Keppler R, Hilbert K, Cormier Daire V, Nikkel S, Nishimura G, et al. Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia. Am J Hum Genet. 2009;85:168-78 pubmed publisher
	Kennedy A, Inada M, Krane S, Christie P, Harding B, Lopez Otin C, et al. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest. 2005;115:2832-42 pubmed

product information

Catalog Number :

MAB13424

Subcategory :

Cell Structure

Product Name :

Anti-MMP-13 Antibody, clone VIIIA2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P45452

Host Name :

Mouse

Antigen :

MMP-13

Clone :

VIIIA2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-13 Antibody, clone VIIIA2

Cross Reactivity :

Human;Mouse;Rabbit

ALT Names :

Collagenase-3

Immunogen :

Human recombinant collagenase-3 protein.

Specificity :

It recognizes proteins of ~60 kDa and ~48 kDa which are identified as pro (latent) and activate forms of matrix metalloproteinase-13 (MMP-13; also known as Collagenase-3). Shows no cross reactivity with the pro and active forms of other MMPs. Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients. The MMP-13 gene has been isolated and characterized. This gene is composed of 10 exons and 9 introns and spans over 12.5 kb. The overall organization of the collagenase-3 gene is similar to that of other MMP genes clustered at chromosome 11q22, including fibroblast collagenase (MMP-1), matrilysin (MMP-7), and macrophage metalloelastase (MMP-12), but is more distantly related to genes coding for stromelysin-3 (MMP-11), gelatinase-A (MMP-2), and gelatinase-B (MMP-9), which map outside of this gene cluster. Cellular Localization: Cytoplasmic

Package Size :

100 µg

Uses :

Immunohistochemistry

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 12 months.