MMP-7 Antibody, clone ID-2 | EMD Millipore MAB13414 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-7 Antibody, clone ID-2

catalog :

MAB13414

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ID-2

The same clone is also sold as:

Invitrogen: MA5-14215
Santa Cruz Biotechnology: sc-58388
LifeSpan Biosciences: LS-C88496, LS-C88495

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 4

Reference
Brejchova K, Liskova P, Cejkova J, Jirsova K. Role of matrix metalloproteinases in recurrent corneal melting. Exp Eye Res. 2010;90:583-90 pubmed publisher
Barnes E, Kenerson H, Mak B, Yeung R. The loss of tuberin promotes cell invasion through the ß-catenin pathway. Am J Respir Cell Mol Biol. 2010;43:617-27 pubmed publisher
Brejchova K, Liskova P, Hrdlickova E, Filipec M, Jirsova K. Matrix metalloproteinases in recurrent corneal melting associated with primary Sjörgen's syndrome. Mol Vis. 2009;15:2364-72 pubmed
Chng W, Remstein E, Fonseca R, Bergsagel P, Vrana J, Kurtin P, et al. Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications. Blood. 2009;113:635-45 pubmed publisher

product information

Catalog Number :

MAB13414

Subcategory :

Cell Structure

Product Name :

Anti-MMP-7 Antibody, clone ID-2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09237

Host Name :

Mouse

Antigen :

MMP-7

Clone :

ID-2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-MMP-7 Antibody, clone ID-2

Cross Reactivity :

Human

Background :

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an approximately 10 kDa segment from the N-terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP). These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in angiogenesis, arthritis, periodontitis, and metastasis. Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials (e.g., 4-aminophenylmercuric acetate, APMA) and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, pancreatic carcinomas and approximately 50% of gliomas.

ALT Names :

Matrilysin; PUMP-1

Immunogen :

Recombinant human matrilysin.

Specificity :

Antibody recognizes proteins of ~28 kDa and ~18 kDa which are identified as pro (latent) and active forms of matrix metalloproteinase-7. The antibody shows no cross-reaction with the pro and active forms of other MMPs. Cellular Localization: Cytoplasmic (Visscher et al., 1994).

Package Size :

100 µg

Uses :

Immunofluorescence;Immunohistochemistry;Immunohistochemistry (Paraffin)

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.