MMP-2 Antibody, pro and active form, clone VB3 | EMD Millipore MAB13406 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-2 Antibody, pro and active form, clone VB3

catalog :

MAB13406

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VB3

The same clone is also sold as:

LifeSpan Biosciences: LS-C88483, LS-C88484, LS-C88485
Invitrogen: MA5-14183, MA5-14186, MS804PABX

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

citations: 3

Reference
Wang K, Hsia S, Chan C, Chang F, Huang C, Bau D, et al. Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin Ther Targets. 2013;17:337-49 pubmed publisher
Pivetta E, Scapolan M, Pecolo M, Wassermann B, Abu Rumeileh I, Balestreri L, et al. MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases. Breast Cancer Res. 2011;13:R105 pubmed publisher
La Rocca G, Anzalone R, Magno F, Farina F, Cappello F, Zummo G. Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts. Respir Res. 2007;8:23 pubmed

product information

Catalog Number :

MAB13406

Subcategory :

Cell Structure

Product Name :

Anti-MMP-2 Antibody, pro and active form, clone VB3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08253

Host Name :

Mouse

Antigen :

MMP-2

Clone :

VB3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-2 Antibody, pro and active form, clone VB3

Cross Reactivity :

Human

ALT Names :

Gelatinase A; 72 kDa Type IV Collagenase

Immunogen :

Human native 72 kDa Gelatinase A.

Specificity :

The antibody recognizes proteins of 72kDa and 66kDa which are identified as pro (latent) and active forms of matrix metalloproteinase-2 (MMP-2; also known as 72 kDa collagenase IV or gelatinase A). Shows no cross-reactivity with pro and active forms of other MMPs. MMPs are proteolytic enzymes capable of degrading connective tissue components. Degradation of the extracellular matrix (ECM) is an essential step in tumor invasion and metastasis. MMPs each have different substrate specificities within the ECM and are important in its degradation. MMP-2 mainly degrades type IV collagen and denatured collagens. MMP activity is modulated by tissue inhibitors of metalloproteinases (TIMP). Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by TIMP have been implicated in the invasive potential of malignant tumors.Cellular Localization: cytoplasmic

Package Size :

100 µg

Uses :

ELISA;Immunofluorescence;Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.