Tryptase Antibody, Mast Cell, clone G3 | EMD Millipore MAB1222 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tryptase Antibody, Mast Cell, clone G3

catalog :

MAB1222

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

G3

The same clone is also sold as:

OriGene: AM10146SU-N, TA327748
Santa Cruz Biotechnology: sc-33676
LifeSpan Biosciences: LS-C348618, LS-C202913

reactivity :

human, domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 3	Kirshenbaum A, Cruse G, Desai A, Bandara G, Leerkes M, Lee C, et al. Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis. PLoS ONE. 2016;11:e0159177 pubmed publisher
immunohistochemistry - frozen section; human; 1:1000; loading ...; tbl 1	Walraven M, Talhout W, Beelen R, van Egmond M, Ulrich M. Healthy human second-trimester fetal skin is deficient in leukocytes and associated homing chemokines. Wound Repair Regen. 2016;24:533-41 pubmed publisher
immunocytochemistry; human	Hoermann G, Blatt K, Greiner G, Putz E, Berger A, Herrmann H, et al. CD52 is a molecular target in advanced systemic mastocytosis. FASEB J. 2014;28:3540-51 pubmed publisher
immunohistochemistry; domestic horse; 1:1000	Zannoni A, Bombardi C, Dondi F, Morini M, Forni M, Chiocchetti R, et al. Proteinase-activated receptor 2 expression in the intestinal tract of the horse. Res Vet Sci. 2014;96:464-71 pubmed publisher
immunohistochemistry - paraffin section; human; 1:12000	Shikhagaie M, Andersson C, Mori M, Kortekaas Krohn I, Bergqvist A, Dahl R, et al. Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma. Clin Exp Allergy. 2014;44:184-96 pubmed publisher
	Hu Frisk J, Kjellen L, Kaler S, Pejler G, Ohrvik H. Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells. J Immunol. 2017;199:4132-4141 pubmed publisher
	Guo Y, Wu Q, Ni B, Mou Z, Jiang Q, Cao Y, et al. Tryptase is a candidate autoantigen in rheumatoid arthritis. Immunology. 2014;142:67-77 pubmed publisher
	Hua X, Chason K, Patel J, Naselsky W, Tilley S. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS ONE. 2011;6:e24947 pubmed publisher
	Amatya B, El Nour H, Holst M, Theodorsson E, Nordlind K. Expression of tachykinins and their receptors in plaque psoriasis with pruritus. Br J Dermatol. 2011;164:1023-9 pubmed publisher
	Klooker T, Braak B, Koopman K, Welting O, Wouters M, van der Heide S, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010;59:1213-21 pubmed publisher
	Wang X, Yip K, Sam S, Lau H. Buffy coat preparation is a convenient source of progenitors for culturing mature human mast cells. J Immunol Methods. 2006;309:69-74 pubmed
	Ständer S, Schmelz M, Metze D, Luger T, Rukwied R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci. 2005;38:177-88 pubmed

product information

Catalog Number :

MAB1222

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Tryptase Antibody, Mast Cell, clone G3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15661

Host Name :

Mouse

Antigen :

Tryptase

Clone :

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Tryptase Antibody, Mast Cell, clone G3

Cross Reactivity :

Human

Background :

Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells. Tryptase has recently been used as a marker for mast cell activation and is involved with allergic response. Tryptase may act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.

Specificity :

Recognizes Mast cell tryptase. Will show reactivity to basophils but to a lesser degree.

Package Size :

100 μg

Uses :

Flow Cytometry;Immunohistochemistry;Western Blotting

Storage :

Maintain at 2–8°C for the duration listed on the product datasheet. (See product datasheet for storage conditions)