Insulin Receptor Antibody, α subunit, azide free, clone 47-9 | EMD Millipore MAB1137Z product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Insulin Receptor Antibody, α subunit, azide free, clone 47-9

catalog :

MAB1137Z

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

47-9

The same clone is also sold as:

LifeSpan Biosciences: LS-C88308, LS-C83495, LS-C88309, LS-C24730, LS-C24729
Invitrogen: MA5-13773

reactivity :

human

product information

Catalog Number :

MAB1137Z

Subcategory :

Cell Signaling

Product Name :

Anti-Insulin Receptor Antibody, α subunit, azide free, clone 47-9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06213

Host Name :

Mouse

Antigen :

Insulin Receptor

Clone :

47-9

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Insulin Receptor Antibody, α subunit, azide free, clone 47-9

Cross Reactivity :

Bovine;Human;Pig;Sheep

ALT Names :

CD220;MAB1137

Immunogen :

IM-9 lymphocytes followed by purified insulin receptor.

Specificity :

Recognizes a protein of 135kDa, identified as the alpha-subunit of insulin receptor (IR). Its epitope localizes in exon 7/8 and shows no cross-reaction with IGF-receptors {Soos, 1986}. Antibody superbly inhibits ( 90%) insulin binding and BLOCKS insulin action. IR is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a beta-a-a-beta configuration. The beta-subunit (95kDa) possesses a single transmembrane domain, whereas the alpha-subunit is completely extracellular. The intracellular portion of the beta-subunit is a tyrosine-specific protein kinase with sequence homology to other such kinases. Activation of kinase is essential in signaling pathway whereby insulin regulates intracellular metabolism.

Package Size :

100 μg

Uses :

Affects Function

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.