Smad4 Antibody, clone SMD46 | EMD Millipore MAB1132 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Smad4 Antibody, clone SMD46

catalog :

MAB1132

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SMD46

The same clone is also sold as:

Santa Cruz Biotechnology: sc-56775

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Reference
Insalaco L, Di Gaudio F, Terrasi M, Amodeo V, Caruso S, Corsini L, et al. Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells. J Cell Mol Med. 2012;16:2186-95 pubmed publisher
Sakairi T, Abe Y, Kopp J. TGF-beta1 reduces Wilms' tumor suppressor gene expression in podocytes. Nephrol Dial Transplant. 2011;26:2746-52 pubmed publisher
Wordinger R, Fleenor D, Hellberg P, Pang I, Tovar T, Zode G, et al. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest Ophthalmol Vis Sci. 2007;48:1191-200 pubmed

product information

Catalog Number :

MAB1132

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Smad4 Antibody, clone SMD46

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13485

Host Name :

Mouse

Antigen :

Smad4

Clone :

SMD46

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Smad4 Antibody, clone SMD46

Cross Reactivity :

Human

ALT Names :

DPC4

Immunogen :

Purified recombinant DPC4 protein.

Specificity :

Recognizes a protein of 60kDa, which is identified as DPC4 (also named SMAD4). Antibody is highly specific and shows no cross-reaction with the other closely related members of this family. The family of SMAD molecules comprises essential mediators of transforming growth factor beta (TGF-b) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-beta superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.

Package Size :

100 µg

Uses :

Immunofluorescence;Immunoprecipitation;Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.