CBX-4 Antibody, clone 10H10.2 | EMD Millipore MAB11012 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CBX-4 Antibody, clone 10H10.2

catalog :

MAB11012

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H10.2

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

MAB11012

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-CBX-4 Antibody, clone 10H10.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O00257

Host Name :

Mouse

Antigen :

CBX-4

Clone :

10H10.2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-CBX-4 Antibody, clone 10H10.2

Cross Reactivity :

Human;Mouse

Background :

Chromeobox 4 (CBX4), also known as Pc2, is a polycomb group (PcG) protein that functions as a transcriptional suppressor. CBX4 is thought to act as a co-repressor of DNMT3B, inducing transcriptional repression independent of DNA methylation. CBX4 also acts as a SUMO E3 ligase, facilitating SUMO1 conjugation by UBE2I. CBX4 is phosphorylated on Thr495 by HIPK2 upon DNA damage, which enhances its E3 SUMO-protein ligase activity.

ALT Names :

chromobox homolog 4

Immunogen :

The immunogen was GST-tagged fusion protein containing amino acids 77-551 of murine CBX-4.

Specificity :

This antibody recognizes CBX-4.

Package Size :

100 μg

Uses :

Western Blotting;Multiplexing

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.