Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1 | EMD Millipore MAB10754 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1

catalog :

MAB10754

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B12.1

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human	Petazzi P, Akizu N, Garcia A, Estarás C, Martinez de Paz A, Rodríguez Paredes M, et al. An increase in MECP2 dosage impairs neural tube formation. Neurobiol Dis. 2014;67:49-56 pubmed publisher

product information

Catalog Number :

MAB10754

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14790

Host Name :

Mouse

Antigen :

Caspase-8 (active form p18 subunit)

Clone :

2B12.1

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1

Cross Reactivity :

Human

Background :

Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death. Caspase-8 is recruited to death-inducing signaling complex (DISC), CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18. Active caspase-8 or the p18 subunit, is the first in the caspase signaling cascade, and it signals downstream caspases to eventually induce apoptosis.

ALT Names :

caspase 8, apoptosis-related cysteine peptidase;caspase-8;caspase 8, apoptosis-related cysteine protease;MACH-beta-1/2/3/4 protein;Apoptotic protease Mch-5;Apoptotic cysteine protease;MACH-alpha-1/2/3 protein;FADD-homologous ICE/ced-3-like protease;MORT1-associated ced-3 homolog;ICE-like apoptotic protease 5;FADD-like ICE

Immunogen :

KLH-conjugated linear peptide corresponding to the active form of human Caspase-8.

Specificity :

This antibody recognizes the active form (p18 subunit) of Caspase-8.

Package Size :

200 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt