Caspase3 (active form) Antibody, clone 3D9.3 | EMD Millipore MAB10753 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase3 (active form) Antibody, clone 3D9.3

catalog :

MAB10753

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D9.3

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig S3	Tonks I, Mukhopadhyay P, Schroder W, Sorolla A, Mould A, Handoko H, et al. Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation. Oncogene. 2017;36:3789-3795 pubmed publisher

product information

Catalog Number :

MAB10753

Subcategory :

Cell Structure

Product Name :

Anti-Caspase3 (active form) Antibody, clone 3D9.3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42574

Host Name :

Mouse

Antigen :

Caspase3 (active form)

Clone :

3D9.3

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-Caspase3 (active form) Antibody, clone 3D9.3

Cross Reactivity :

Human

Background :

Caspase-3 (CPP32, Apopain) is the most extensively studied apoptotic protein. Caspase-3 is synthesized as an inactive proenzyme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kDa) and small (12 kDa) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells such as PARP and DFF.

ALT Names :

Caspase-3;CASP-3;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1;Caspase-3 subunit p17;Caspase-3 subunit p12

Immunogen :

KLH-conjugated linear peptide corresponding to human Caspase3 (active form).

Specificity :

This antibody demonstrates specificity for the cleaved 17 kDa active form, but does not cross-react with the non-active (pro) form Caspase3 at 35 kDa.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt