TRAIL-R2 Antibody, clone YM366 | EMD Millipore MAB10418 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TRAIL-R2 Antibody, clone YM366

catalog :

MAB10418

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

YM366

reactivity :

human

application :

flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 3	Greene L, Nathwani S, Zisterer D. Inhibition of ?-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5. Oncol Lett. 2016;12:2900-2905 pubmed

product information

Catalog Number :

MAB10418

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-TRAIL-R2 Antibody, clone YM366

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O14763

Host Name :

Mouse

Antigen :

TRAIL-R2

Clone :

YM366

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-TRAIL-R2 Antibody, clone YM366

Cross Reactivity :

Human;Mouse

Background :

TRAIL-R2 is also known as soluble Death Receptor 5 (sDR5), a single-pass type I membrane protein belonging to the tumor necrosis factor receptor superfamily and is comprised of a single death domain and three TNFR-Cys repeats. Through association of its death domain to cytotoxic ligand TRAIL and related receptor DR4, TRAIL-R2 is a component of the preapoptotic death-inducing signaling complex, the formation of which induces proteolytic activation of caspase-8 resulting in regulated apoptosis. TRAIL-R2 also upregulates the activation of NF-kappa-B. It is expressed in a wide variety of fetal and adult tissues including heart, liver, pancreas, testis, esophagus, prostate, ovary, stomach, spleen, thymus and peripheral blood lymphocytes. It is not expressed in the brain. Defects in TRAIL-R2 are thought to cause head and neck squamous cell carcinomas (HNSCC).

ALT Names :

tumor necrosis factor receptor superfamily member 10b;soluble Death Receptor 5;sDR5;CD262;p53-regulated DNA damage-inducible cell death receptor (killer);death domain containing receptor for TRAIL/Apo-2L;cytotoxic TRAIL receptor-2;tumor necrosis factor receptor-like protein ZTNFR9;TNF-related apoptosis-inducing ligand receptor 2

Immunogen :

Histidine-tagged recombinant protein corresponding to human TRAIL-R2.

Package Size :

100 μg

Uses :

Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt