Cathepsin K Mouse mAb (182-12G5) | EMD Millipore IM55-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cathepsin K Mouse mAb (182-12G5)

catalog :

IM55-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

IM55-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Cathepsin K Mouse mAb (182-12G5)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1513 (Hu), 13038 (Ms), 29175 (Rt)

Host Name :

Clone :

182-12G5

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Cathepsin K Mouse mAb (182-12G5)

Cross Reactivity :

Human

Background :

Cathepsins are normal lysosomal proteases, which are expressed in all cells where they function in protein turnover. They have also been shown to be capable of degrading extracellular matrix proteins.Cathepsin K, also known as OC-2, is a cysteine endoproteinase that is predominantly expressed in osteoclasts and is structurally and functionally related to cathepsin L and cathepsin S. The cloned human cDNA encodes a protein of 329 amino acids showing a 94% homology to rabbit cathepsin K. Northern blot analysis show elevated levels of cathepsin K mRNA in osteoarthritic hip bones and very high levels in osteoclastoma compared to low levels in other tissues such as kidney, liver, spleen and lung. The predominant expression of cathepsin K in osteoclasts suggests an important role in human osteoclastic bone resorption and may provide possible rationale for the treatment of osteoporosis and certain forms of arthritis.

ALT Names :

AI323530, CATHEPSIN K, catK, CTS02, CTSO, CTSO1, CTSO2, MGC23107, MMS10-Q, Ms10q, PKND, PYCD, cathepsin K

Immunogen :

a synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K

Specificity :

Recognizes the ~28 kDa cathepsin K protein.

Package Size :

100 ug

Uses :

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.