MMP-2 (Ab-4) Mouse mAb (75-7F7) | EMD Millipore IM51-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-2 (Ab-4) Mouse mAb (75-7F7)

catalog :

IM51-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

IM51-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-MMP-2 (Ab-4) Mouse mAb (75-7F7)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4313 (Hu), 17390 (Ms), 81686 (Rt)

Host Name :

Clone :

75-7F7

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-2 (Ab-4) Mouse mAb (75-7F7)

Cross Reactivity :

Bovine, Human, Mouse

Background :

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an ~10 kDa segment from the N-terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP). These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.MMP-2 (Gelatinase A, 72 kDa gelatinase, type IV collagenase, TBE-1) is secreted as a 72 kDa zymogen which is proteolytically processed to the 66 kDa active form.

ALT Names :

CLG4, CLG4A, GELA, GELATINASE, GELATINASE A, MMP-II, MONA, Neutrophil Gelatinase, TBE-1, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Immunogen :

human MMP-2 derived from conditioned medium of CCD-41SK skin fibroblasts

Specificity :

Recognizes the ~72 kDa latent and the ~66 kDa active forms of MMP-2.

Package Size :

100 ug

Uses :

IH, WB, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.