TIMP-3 Mouse mAb (136-13H4) | EMD Millipore IM43-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TIMP-3 Mouse mAb (136-13H4)

catalog :

IM43-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

IM43-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-TIMP-3 Mouse mAb (136-13H4)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

7078 (Hu), 21859 (Ms), 25358 (Rt)

Host Name :

Clone :

136-13H4

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-TIMP-3 Mouse mAb (136-13H4)

Cross Reactivity :

Baboon, Human, Rabbit

Background :

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin, and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an ~10 kDa segment from the N-terminus, and their activity is regulated by endogenous inhibitors. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitiors of metalloproteinase (TIMP).

ALT Names :

HSMRK222, K222, K222TA2, SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory), Timp-3, timp3, MIG-5, TIMP metallopeptidase inhibitor 3

Immunogen :

a synthetic peptide corresponding to amino acids 170-188 of human TIMP-3

Specificity :

Recognizes both the ~27 kDa glycosylated and the ~24 kDa unglycosylated forms of TIMP-3.

Package Size :

100 ug

Uses :

IH, WB, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.