MT1-MMP (Ab-3) Mouse mAb (114-6G6) | EMD Millipore IM42-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MT1-MMP (Ab-3) Mouse mAb (114-6G6)

catalog :

IM42-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

IM42-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-MT1-MMP (Ab-3) Mouse mAb (114-6G6)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4323 (Hu), 17387 (Ms), 81707 (Rt)

Host Name :

Clone :

114-6G6

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MT1-MMP (Ab-3) Mouse mAb (114-6G6)

Cross Reactivity :

Human

Background :

Matrix metalloproteinases (MMP's) are a family of enzymes that are responsible for the degradation of extracellular matrix components. Of the sixteen proteins reported to date, ten are normally found as soluble molecules. Several of the MMP proteins have been shown to be integral membrane proteins and have been named MT-MMP's for membrane bound MMP. The MT-MMP family is now known to contain at least three members, MT1-MMP, MT2-MMP and MT3-MMP also known as MMP-14, MMP-15 and MMP-16 respectively. While each of these proteins contain a C-terminal transmembrane domain allowing localization to the cell surface they are independently expressed. These proteins are also unique from the other members of the MMP family in that they contain an 8 amino acid insert in the catalytic domain. The MT1-MMP protein is encoded by a 4.5 kb mRNA species giving rise to a protein with a molecular weight of 60 66 kDa by SDS-PAGE.

ALT Names :

AI325305, MMP-X1, MT-MMP, MT-MMP-1, MT1-MMP, matrix metallopeptidase 14 (membrane-inserted)

Immunogen :

a synthetic peptide (REVPYAYIREGHEK) corresponding to amino acids 160-173 in the catalytic domain of human MT1-MMP

Specificity :

Recognizes the ~66 kDa latent and the ~60 kDa active forms of MT1-MMP protein.

Package Size :

100 ug

Uses :

WB, IC, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.