MMP-7 (Ab-1) Mouse mAb (141-7B2) | EMD Millipore IM40-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-7 (Ab-1) Mouse mAb (141-7B2)

catalog :

IM40-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

IM40-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-MMP-7 (Ab-1) Mouse mAb (141-7B2)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4316 (Hu), 17393 (Ms), 25335 (Rt)

Host Name :

Clone :

141-7B2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-7 (Ab-1) Mouse mAb (141-7B2)

Cross Reactivity :

Human

Background :

The matrix metalloproteinases (MMP's) are a family of enzymes responsible for the degradation of extracellular matrix components. Of the eleven proteins reported to date, ten are normally found as soluble molecules. MMP-7, also known as matrilysin, is responsible for hydrolyzing proteoglycans and extracellular matrix glycoproteins and was first described in 1980 but not purified to homogeneity until 1988. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. The enzyme exists as an inactive pro form with a molecular weight of ~28 kDa (range: 28-30 kDa) which becomes activated by proteolytic cleavage to an active 19 kDa form. Pro-MMP-7 may be activated by trypsin, mercurial compounds or by MMP-3 and once activated can itself activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2.

ALT Names :

MAT, MATRILYSIN, MPMM, MPSL1, PUMP-1, matrix metallopeptidase 7 (matrilysin, uterine)

Immunogen :

human rectal carcinoma MMP-7

Specificity :

Recognizes the ~28 kDa latent form of MMP-7.

Package Size :

100 ug

Uses :

WB, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.