MMP-8 (Ab-1) Mouse mAb (115-13D2) | EMD Millipore IM38-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-8 (Ab-1) Mouse mAb (115-13D2)

catalog :

IM38-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

IM38-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-MMP-8 (Ab-1) Mouse mAb (115-13D2)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4317 (Hu), 17394 (Ms), 63849 (Rt)

Host Name :

Clone :

115-13D2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-8 (Ab-1) Mouse mAb (115-13D2)

Cross Reactivity :

Human

Background :

Matrix metalloproteinases (MMP's) are a family of enzymes that are responsible for the degradation of extracellular matrix components. Of the eleven proteins reported to date, ten are normally found as soluble molecules. MMP-8, also known as polymorphonuclear leukocyte collagenase, is a collagenolytic enzyme first described in 1986. MMP-8 is closely related to the fibroblast collagenases (47% homology) but is encoded by a different gene. The enzyme exists as an inactive pro form with a molecular weight of approximately 85 kDa of which 35% is contributed by glycosylation. MMP-8 becomes activated by removal of the amino terminal pro-peptide which can be effected by trypsin but not by cell bound plasmin in a two step process. MMP-8 also will undergo autoproteolysis a process which can also be mediated by mercurial compounds.

ALT Names :

BB138268, CLG1, COLLAGENASE 1, Collagenase 2, HNC, Neutrophil Collagenase, PMNL-CL, matrix metallopeptidase 8 (neutrophil collagenase)

Immunogen :

human MMP-8

Specificity :

Recognizes the ~85 kDa latent and the ~64 kDa active forms of MMP-8.

Package Size :

100 ug

Uses :

WB, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.