uPA (Ab-1) Mouse mAb (5) | EMD Millipore IM13L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

uPA (Ab-1) Mouse mAb (5)

catalog :

IM13L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

IM13L-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-uPA (Ab-1) Mouse mAb (5)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

5328 (Hu), 18792 (Ms), 25619 (Rt)

Host Name :

Clone :

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-uPA (Ab-1) Mouse mAb (5)

Cross Reactivity :

Human

Background :

Urokinase-type plasminogen activator (uPA) is a serine proteinase that functions in the conversion of plasminogen to the active proteinase, plasmin1. It is secreted from cells as an inactive 52 kDa precursor (single-chain or sc-uPA) which is activated to the two-chain form consisting of an A and B-chain. The active high molecular weight form (HMW-uPA) can be further processed by removal of an amino-terminal fragment (ATF) to an active low molecular weight form (LMW-uPA) of 33 kDa. The B-chain contains the active site and binds the two endogenous plasminogen activator inhibitors, PAI-1 and PAI-22. The binding of pro-uPA to its cell surface receptor enhances its rate of activation3. uPA is responsible for normal physiological processes such as tissue remodeling and cell migration. Since cell surface plasminogen activation is involved in extracellular matrix degradation, uPA is likely to play a key role in the process of invasion and metastasis.

ALT Names :

ATF, MGC124931, MGC139972, SCUPA, U-PA, uPA 50 kd form, UPA-H, UPAM, URK, UROKINASE, plasminogen activator, urokinase

Immunogen :

human urine urokinase plasminogen activator

Specificity :

Recognizes uPA/PAI complexes and receptor-bound uPA.

Package Size :

100 ug

Uses :

IH, WB, IP, IH(P)

Storage :

We recommend resuspending the lyophilized antibody with sterile phosphate buffered saline (PBS), pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to yield a final concentration of 100 ug/ml. Lyophilized antibodies should be resuspended at 4°C with occasional gentle mixing for at least 2 h. Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) with 0.1% azide for short-term storage. Avoid freeze/thaw cycles.