Matriptase/MT-SP1 Rabbit pAb | EMD Millipore IM1014-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Matriptase/MT-SP1 Rabbit pAb

catalog :

IM1014-50UG

quantity :

50 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 2b western blot; human; loading ...; fig 6c	Wu C, Feng X, Lu M, Morimura S, Udey M. Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis. J Clin Invest. 2017;127:623-634 pubmed publisher

product information

Catalog Number :

IM1014-50UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Matriptase/MT-SP1 Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

6768 (Hu), 19143 (Ms), 114093 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Matriptase/MT-SP1 Rabbit pAb

Cross Reactivity :

Human

Background :

Matriptase (MT-SP1, ACC. No. NP_068813), a type II membrane serine protease, may play important roles in cell migration and tumor cell metastasis. It is a mosaic protein with broad spectrum cleavage activity and two potential regulatory modules. Matriptase can convert hepatocyte growth factor/scatter factor to its active form, which can then activate c-Met tyrosine phosphorylation. Furthermore, protease-activated receptor 2 (PAR2) and enzymatically inactive single-chain uPA (pro-uPA) were identified as substrates of matriptase. Matriptase may regulate PAR2 mediated functions such as inflammatory responses, cell adhesion, and uPA-dependent tumor cell invasion and metastasis. The expression of matriptase is associated with a more invasive phenotype.

ALT Names :

Epithin, HAI, MATRIPTASE, MT-SP1, PRSS14, SNC19, TADG15, suppression of tumorigenicity 14 (colon carcinoma)

Immunogen :

a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase

Specificity :

Recognizes the ~75 kDa matriptase protein.

Package Size :

50 ug

Uses :

WB, IP

Storage :

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.