Cathepsin D (Ab-1) Mouse mAb (BC011) | EMD Millipore IM03-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cathepsin D (Ab-1) Mouse mAb (BC011)

catalog :

IM03-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

Japanese rice fish, human, mouse, rat

application :

western blot, immunohistochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:100; loading ...; fig 4c	Vidoni C, Secomandi E, Castiglioni A, Melone M, Isidoro C. Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation. Neurochem Int. 2018;117:174-187 pubmed publisher
immunohistochemistry; Japanese rice fish; 1:200; fig 4	Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa Fujiwara T, Matsui H, et al. Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. PLoS Genet. 2015;11:e1005065 pubmed publisher

product information

Catalog Number :

IM03-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Cathepsin D (Ab-1) Mouse mAb (BC011)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1509 (Hu), 13033 (Ms), 171293 (Rt)

Host Name :

Clone :

BC011

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Cathepsin D (Ab-1) Mouse mAb (BC011)

Cross Reactivity :

Human

Background :

Cathepsin D is a normal lysosomal proteinase which is expressed in all cells. It is an aspartyl proteinase with a pH optimum in the range of 3-5 and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid pro-fragment and internal cleavage to generate the two chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal which targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

ALT Names :

CATD, CATHEPSIN D, CD, CLN10, CPSD, LOC196214, MGC2311, cathepsin D

Immunogen :

mature, human cathepsin D

Specificity :

Recognizes the ~52 kDa pro-cathespin D, the ~48 kDa mature cathepsin D, and the ~34 kDa subunit of cathespin D.

Package Size :

100 ug

Uses :

WB, IH(P)

Storage :

Do not freeze