Calbindin D-28K Antibody, prediluted | EMD Millipore IHCR1013-6 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Calbindin D-28K Antibody, prediluted

catalog :

IHCR1013-6

quantity :

6 mL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

IHCR1013-6

Subcategory :

Neuroscience

Product Name :

Anti-Calbindin D-28K Antibody, prediluted

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05937

Host Name :

Rabbit

Antigen :

Calbindin D-28K

Conjugate :

Purified

Product Description :

Anti-Calbindin D-28K Antibody, prediluted

Cross Reactivity :

Human

Background :

Calbindin D28k is a member of a large family of intracellular calcium-binding proteins of the EF-hand related to calmodulin and troponin-C. The biological roles of Calbindin D28k include, calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to several disease states. Decline in calbindin D28k in hippocampal dentate granule cells correlates with the kindling model for epilepsy. Calbindin D28k immunoreactivity is specifically absent from neuronal poplulations lost early in ALS, while substantial loss of neurons which do contain the protein occur in patients with Huntington's disease.

Immunogen :

Purified recombinant calbindin.

Specificity :

Calbindin. Shows no cross-reactivity to calretinin by Western blot. The antibody produces specific staining of cerebellum Purkinje cells, molecular layer dendrites and axonal fibers, stains cell bodies and fibers in neuronal subpopulations.

Package Size :

6 mL

Uses :

Immunohistochemistry (Paraffin)

Storage :

Maintain at 2-8oC. Refer to vial for expiration dating.