Tyrosine Hydroxylase Antibody, prediluted, clone LNC1 | EMD Millipore IHCR1005-6 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tyrosine Hydroxylase Antibody, prediluted, clone LNC1

catalog :

IHCR1005-6

quantity :

6 mL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LNC1

reactivity :

human, rat, chicken, fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 25

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; fruit fly ; 1:200; loading ...; fig 2a western blot; human; 1:1000; fig 4	Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
immunohistochemistry - frozen section; rat; fig 1	Liu Z, Brown A, Fisher D, Wu Y, Warren J, Cui X. Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. PLoS ONE. 2016;11:e0149379 pubmed publisher
immunohistochemistry; human; 1:100	Rohn T, Catlin L. Immunolocalization of influenza A virus and markers of inflammation in the human Parkinson's disease brain. PLoS ONE. 2011;6:e20495 pubmed publisher
	Nomura S, Bouhadana M, Morel C, Faure P, Cauli B, Lambolez B, et al. Noradrenalin and dopamine receptors both control cAMP-PKA signaling throughout the cerebral cortex. Front Cell Neurosci. 2014;8:247 pubmed publisher
	Forlano P, Kim S, Krzyminska Z, Sisneros J. Catecholaminergic connectivity to the inner ear, central auditory, and vocal motor circuitry in the plainfin midshipman fish porichthys notatus. J Comp Neurol. 2014;522:2887-927 pubmed publisher
	Bloch J, Brunet J, McEntire C, Redmond D. Primate adult brain cell autotransplantation produces behavioral and biological recovery in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian St. Kitts monkeys. J Comp Neurol. 2014;522:2729-40 pubmed publisher
	Bilandzija H, Ma L, Parkhurst A, Jeffery W. A potential benefit of albinism in Astyanax cavefish: downregulation of the oca2 gene increases tyrosine and catecholamine levels as an alternative to melanin synthesis. PLoS ONE. 2013;8:e80823 pubmed publisher
	Wang Z, Myers K, Guo Y, Ocampo M, Pang R, Jakowec M, et al. Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism. PLoS ONE. 2013;8:e80058 pubmed publisher
	Karten H, Brzozowska Prechtl A, Lovell P, Tang D, Mello C, Wang H, et al. Digital atlas of the zebra finch (Taeniopygia guttata) brain: a high-resolution photo atlas. J Comp Neurol. 2013;521:3702-15 pubmed publisher
	Febbraro F, Sahin G, Farran A, Soares S, Jensen P, Kirik D, et al. Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease. Neurobiol Dis. 2013;56:47-58 pubmed publisher
	Korecka J, Eggers R, Swaab D, Bossers K, Verhaagen J. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restor Neurol Neurosci. 2013;31:155-67 pubmed publisher
	Grant W, Nicol L, Thorn S, Grove K, Friedman J, Marks D. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS ONE. 2012;7:e48119 pubmed publisher
	Bilandzija H, Cetkovic H, Jeffery W. Evolution of albinism in cave planthoppers by a convergent defect in the first step of melanin biosynthesis. Evol Dev. 2012;14:196-203 pubmed publisher
	Darland T, Mauch J, Meier E, Hagan S, Dowling J, Darland D. Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1? in zebrafish. Pharmacol Biochem Behav. 2012;103:157-67 pubmed publisher
	Herrik K, Redrobe J, Holst D, Hougaard C, Sandager Nielsen K, Nielsen A, et al. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012;3:11 pubmed publisher
	Sapsford T, Kokay I, Ostberg L, Bridges R, Grattan D. Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action. J Comp Neurol. 2012;520:1062-77 pubmed publisher
	Goemaere J, Knoops B. Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders. J Comp Neurol. 2012;520:258-80 pubmed publisher
	Chang H, Rumbeiha W, Patterson J, Puschner B, Knight A. Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia. Vet Pathol. 2012;49:398-402 pubmed publisher
	Adrio F, Rodriguez Moldes I, Anadón R. Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): comparison with ?-aminobutyric acid. J Comp Neurol. 2011;519:1115-42 pubmed publisher
	Bøttger P, Tracz Z, Heuck A, Nissen P, Romero Ramos M, Lykke Hartmann K. Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain. J Comp Neurol. 2011;519:376-404 pubmed publisher
	Gayoso J, Castro A, Anadón R, Manso M. Differential bulbar and extrabulbar projections of diverse olfactory receptor neuron populations in the adult zebrafish (Danio rerio). J Comp Neurol. 2011;519:247-76 pubmed publisher
	Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner C, Bauer M, et al. A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol Cell Proteomics. 2011;10:M110.001172 pubmed publisher
	Ono Y, Terashima K, Liu A, Yokoyama M, Yokoshima K, Mizukami M, et al. Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. Pathol Int. 2009;59:332-44 pubmed publisher
	Matsuda W, Furuta T, Nakamura K, Hioki H, Fujiyama F, Arai R, et al. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. J Neurosci. 2009;29:444-53 pubmed publisher
	Luuk H, Koks S, Plaas M, Hannibal J, Rehfeld J, Vasar E. Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome. J Comp Neurol. 2008;509:642-60 pubmed publisher

product information

Catalog Number :

IHCR1005-6

Subcategory :

Neuroscience

Product Name :

Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P07101

Host Name :

Mouse

Antigen :

Tyrosine Hydroxylase

Clone :

LNC1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1

Cross Reactivity :

Chicken;Human;Mouse;Monkey;Rat;Frog;Lizard;Vole;Zebrafish

Background :

Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.

Immunogen :

Tyrosine Hydroxylase purified from PC12 cells.

Specificity :

Tyrosine Hydroxylase. Recognizes a protein of approximately 59-63 kDa by Western blot. Does not react with the following on Western Blots: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, phenethanolamine-N-methyl transferase (PNMT).

Package Size :

6 mL

Uses :

Immunohistochemistry (Paraffin)

Storage :

Maintain at 2-8°C. Refer to vial for expiration dating.