Insulin Receptor (beta-Subunit) Mouse mAb (CT-3) | EMD Millipore GR36-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Insulin Receptor (beta-Subunit) Mouse mAb (CT-3)

catalog :

GR36-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a	BjÃ¶rner S, Rosendahl A, Simonsson M, Markkula A, JirstrÃ¶m K, Borgquist S, et al. Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatmen. Oncotarget. 2017;8:9093-9107 pubmed publisher

product information

Catalog Number :

GR36-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-Insulin Receptor (beta-Subunit) Mouse mAb (CT-3)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3643 (Hu), 16337 (Ms), 24954 (Rt)

Host Name :

Clone :

CT-3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Insulin Receptor (beta-Subunit) Mouse mAb (CT-3)

Cross Reactivity :

Human, Mouse, Rat

Background :

Insulin initiates its effects on cells through interaction with high-affinity, cell surface, glycoprotein receptors, consisting of two alpha (~135 kDa) and two beta (~95 kDa) subunits linked by disulfide bonds. The alpha subunits, which are completely extracellular, bind insulin and the beta subunits possessing a single transmembrane domain become phosphorylated in response to insulin. Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain. The receptor protein-tyrosine kinase has been implicated as the mediator of most, if not all, of the effects of insulin. Mutations that diminish both phosphorylation and internalization of the insulin receptor block insulin action, as do antibodies, which inhibit its protein-tyrosine kinase activity. Cells from patients with diabetic syndromes, characterized by non-responsiveness to insulin, exhibit reduced insulin dependent protein-tyrosine kinase activity.

ALT Names :

ALPHA SUBUNIT INSULIN RECEPTOR, CD220, HHF5, INSULIN RECEPTOR, INSULIN RECEPTOR B, Insulin receptor beta, INSULIN RECEPTOR KINASE, INSULIN RPTK, IR, IR ALPHA, IR-B, IRK, insulin receptor

Immunogen :

a recombinant protein consisting of the C-terminal 100 amino acids of the beta-subunit of human insulin receptor fused to GST

Specificity :

Recognizes the ~95 kDa the beta-subunit of insulin receptor.

Package Size :

100 ug

Uses :

IH, WB, IH(P)

Storage :

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles. Centrifuge the contents of the vial containing the antibody before use to remove any solution that may have accumulated around or under the cap of the vial during shipment or storage. Avoid repeated freeze-thaw.