IGF-IR (Ab-3) Mouse mAb (33255.111) | EMD Millipore GR31L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-IR (Ab-3) Mouse mAb (33255.111)

catalog :

GR31L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, neutralization

product information

Catalog Number :

GR31L-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-IGF-IR (Ab-3) Mouse mAb (33255.111)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3480 (Hu), 16001 (Ms), 25718 (Rt)

Host Name :

Clone :

33255.111

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-IGF-IR (Ab-3) Mouse mAb (33255.111)

Cross Reactivity :

Human

Background :

The insulin growth factor (IGF) family, which includes IGF-I and IGF-II, binds to the IGF receptors (IGFRs) to mediate a number of biological effects. At least six IGF binding proteins (IGFBP-1-6) have also been identified which complex with the IGFs to modulate interactions with the receptors in either a stimulatory or inhibitory manner. Expression of these proteins is regulated during development, and is both tissue and cell specific. IGF-I exhibits potent effects on motor neuron survival, modulates neurotransmitter activity, and reduces apoptosis during normal development and axotomy. In addition, IGF-I serves a neuroprotective role against beta-amyloid induced toxicity. It has also been demonstrated that IGF-I, IGF-II, and several IGFBPs are spatiotemporally regulated following hypoxic-ischaemic brain injuries.

ALT Names :

CD221, hyft, IGF-IR, IGF1 RECEPTOR, Igf1r beta, Igf1r beta isoform, IGFIRC, IGFR, IGFR1, JTK13, LOC51049, MGC142170, MGC142172, MGC18216, NM1, insulin-like growth factor 1 receptor

Immunogen :

recombinant, human, soluble IGF-I receptor

Specificity :

Recognizes the ~250-260 kDa IGF-1 receptor protein.

Package Size :

100 ug

Uses :

ELISA, WB, NEUT

Storage :

Reconstitute with sterile PBS to the desired concentration. Following reconstitution, antibody can be stored at 4°C for up to 1 month. For long-term storage, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.