IGF-IR (Ab-1) Mouse mAb (alphaIR3) | EMD Millipore GR11L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-IR (Ab-1) Mouse mAb (alphaIR3)

catalog :

GR11L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunocytochemistry, neutralization, immunoprecipitation

product information

Catalog Number :

GR11L-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-IGF-IR (Ab-1) Mouse mAb (alphaIR3)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3480 (Hu), 16001 (Ms), 25718 (Rt)

Host Name :

Clone :

alphaIR3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-IGF-IR (Ab-1) Mouse mAb (alphaIR3)

Cross Reactivity :

Human

Background :

The insulin-like growth factors (IGFs) or somatomedins are mitogenic peptides present in the plasma of human, rat, and other species. Two distinct but chemically related IGFs have been purified from human plasma: IGF-I (Somatomedin C) and IGF-II. They are single chain polypeptides with molecular weights of 7,640 and 7,471, respectively. Types I and II IGF receptors differ in their structure and in their peptide binding specificity. Type I IGF receptors are structurally homologous to insulin receptors and contain a-subunits (MW = 130,000) that bind peptide, and b-subunits (MW = 90,000), which have intrinsic tyrosine kinase activity. The protein-tyrosine kinase activity of the insulin receptor and, presumably the IGF-I receptor, is required for insulin to stimulate all of its biological responses in cells. Type II receptors are a single polypeptide (MW = 260,000), lack protein-tyrosine kinase activity, and have been shown to be identical to the mannose-6-phosphate receptor.

ALT Names :

CD221, hyft, IGF-IR, IGF1 RECEPTOR, Igf1r beta, Igf1r beta isoform, IGFIRC, IGFR, IGFR1, JTK13, LOC51049, MGC142170, MGC142172, MGC18216, NM1, insulin-like growth factor 1 receptor

Immunogen :

partially purified, human placenta IGF-I receptor

Specificity :

Recognizes the ~130 kDa alpha and the ~90 kDa beta subunits of IGF-I receptor.

Package Size :

100 ug

Uses :

IF, IP, NEUT

Storage :

Reconstitute with sterile phosphate buffered saline (PBS), pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to a final concentration of 100 ug/ml. Lyophilized antibodies should be resuspended at 4°C with occasional gentle mixing for at least two h. Following reconstitution, aliquot and freeze (-20°C) or refrigerate (4°C) with 0.1% sodium azide. Freezing of aliquots is recommended for long term storage of reconstituted product. Avoid freeze/thaw cycles of solutions.