Transferrin Receptor (Ab-1) Mouse mAb (T56/14) | EMD Millipore GR08L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Transferrin Receptor (Ab-1) Mouse mAb (T56/14)

catalog :

GR08L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

GR08L-100UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Transferrin Receptor (Ab-1) Mouse mAb (T56/14)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

7037 (Hu), 22042 (Ms), 64678 (Rt)

Host Name :

Clone :

T56/14

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Transferrin Receptor (Ab-1) Mouse mAb (T56/14)

Cross Reactivity :

Human

Background :

Transferrin is the major iron binding protein in human plasma and is bound by a specific cell surface receptor during transport of iron into various tissues. The human transferrin receptor was originally isolated from placenta and shown to contain a subunit with an apparent molecular weight of 90,000. Further structural characterization of the receptor revealed that it resides in the plasma membrane as a 180,000 dimer, has a pI of 5.2, is phosphorylated predominantly on serine residues and contains both complex and high mannose oligosaccharide chains. Transferrin receptor is considered to be a marker for proliferating cells and its levels can be drastically reduced by agents which cause differentiation of undifferentiated cells such as HL-60 cells. Since many of the enzymes of metabolically active, proliferating cells require iron to catalyze redox reactions it is not surprising that the transferrin receptor would be a marker of proliferation.

ALT Names :

Mtvr-1, p90, TFNR, TFR, TFR1, TRANSFERRIN RECEPTOR, TRANSFERRIN RECEPTOR 1, TRFR, transferrin receptor (p90, CD71)

Immunogen :

K562 cells

Specificity :

Recognizes the ~90 kDa (monomeric) and the ~180 kDa (dimeric) transferrin receptor protein.

Package Size :

100 ug

Uses :

FC, IF, IP

Storage :

We recommend resuspending the lyophilized antibody with sterile PBS, pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to yield a final concentration of 100 ug/ml; product will be more stable if 0.1% sodium azide is included (do not add sodium azide if antibody is to be used with viable cells). Lyophilized antibodies should be resuspended at 4°C with occasional gentle mixing for at least 2 h. Following reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles of solutions.