Insulin Receptor (Ab-3) Mouse mAb (29B4) | EMD Millipore GR07-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Insulin Receptor (Ab-3) Mouse mAb (29B4)

catalog :

GR07-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

neutralization, immunoprecipitation

product information

Catalog Number :

GR07-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-Insulin Receptor (Ab-3) Mouse mAb (29B4)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3643 (Hu), 16337 (Ms), 24954 (Rt)

Host Name :

Clone :

29B4

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Insulin Receptor (Ab-3) Mouse mAb (29B4)

Cross Reactivity :

Human, Mouse, Rat

Background :

Insulin initiates its effects on cells through interaction with high-affinity, cell surface, glycoprotein receptors, consisting of two alpha (135,000 dalton) and two beta (95,000 dalton) subunits linked by disulfide bonds. The alpha subunits bind insulin and the beta subunits become phosphorylated in response to insulin. Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain. The receptor protein-tyrosine kinase has been implicated as the mediator of most, if not all, of the effects of insulin. Mutations that diminish both phosphorylation and internalization of the insulin receptor block insulin action, as do antibodies which inhibit its protein-tyrosine kinase activity. Cells from patients with diabetic syndromes, characterized by nonresponsiveness to insulin, exhibit reduced insulin dependent protein-tyrosine kinase activity.

ALT Names :

ALPHA SUBUNIT INSULIN RECEPTOR, CD220, HHF5, INSULIN RECEPTOR, INSULIN RECEPTOR B, Insulin receptor beta, INSULIN RECEPTOR KINASE, INSULIN RPTK, IR, IR ALPHA, IR-B, IRK, insulin receptor

Immunogen :

partially purified, human, placental insulin receptor

Specificity :

Recognizes the ~95 kDa beta chain of insulin receptor.

Package Size :

100 ug

Uses :

IP, NEUT

Storage :

Do not freeze