BDNF Mouse mAb (35928.11) | EMD Millipore GF35L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BDNF Mouse mAb (35928.11)

catalog :

GF35L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, neutralization, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat; 1:250; loading ...; fig 2b	Telegina D, Kolosova N, Kozhevnikova O. Immunohistochemical localization of NGF, BDNF, and their receptors in a normal and AMD-like rat retina. BMC Med Genomics. 2019;12:48 pubmed publisher

product information

Catalog Number :

GF35L-100UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-BDNF Mouse mAb (35928.11)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

627 (Hu), 12064 (Ms), 24225 (Rt)

Host Name :

Clone :

35928.11

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-BDNF Mouse mAb (35928.11)

Cross Reactivity :

Human

Background :

Neurotrophic factors define a family of related proteins, which are important in the development, maintenance, and regulation of neurons in both the peripheral and central nervous system. In addition to the prototypical nerve growth factor (NGF), several other factors have been identified which interact with a family of tyrosine kinase receptors. TrkA is the kinase signaling receptor for NGF, while TrkB mediates signaling for both brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). TrkC is the primary receptor for neurotrophin-3 (NT-3), although this neurotrophin can also activate TrkA and TrkB receptors under certain conditions. Axotomy-induced cell death is one experimental paradigm that has been used to discriminate between the effects of various neurotrophic factors on the survival of different neuronal populations. BDNF, NT-3, and NT-4/5 act as motor neuron survival factors, whereas NGF has no effect on the survival of spinal cord motor neurons.

ALT Names :

Brain derived neurotrophic factor, MGC105254, MGC34632, OCD1, brain-derived neurotrophic factor

Immunogen :

recombinant protein consisting of amino acids 129-247 of human BDNF

Specificity :

Recognizes the ~20 kDa BDNF protein.

Package Size :

100 ug

Uses :

ELISA, WB, IH, NEUT

Storage :

We recommend resuspending the lyophilized antibody with sterile PBS, pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to yield a final concentration of 100 ug/ml. Following reconstitution, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.