Milli-Mark® Anti-Chk2-FITC Antibody, clone 7 | EMD Millipore FCMAB424F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark® Anti-Chk2-FITC Antibody, clone 7

catalog :

FCMAB424F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

FCMAB424F

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Milli-Mark® Anti-Chk2-FITC Antibody, clone 7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O96017

Host Name :

Mouse

Antigen :

Chk2-FITC

Clone :

Conjugate :

FITC

Isotype :

IgG1

Product Description :

Milli-Mark® Anti-Chk2-FITC Antibody, clone 7

Cross Reactivity :

Human

Background :

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53. Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer.

ALT Names :

CHK2 (checkpoint, S.pombe) homolog;CHK2 checkpoint homolog (S. pombe);checkpoint-like protein CHK2;protein kinase CHK2;serine/threonine-protein kinase CHK2

Immunogen :

Mixture of two GST fusion proteins corresponding to residues 1-223 and 217-543 of human Chk2

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.