Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2 | EMD Millipore FCMAB411F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

catalog :

FCMAB411F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

3H2

The same clone is also sold as:

MyBioSource: MBS530217
Abnova: MAB3491

reactivity :

human, mouse

application :

flow cytometry

product information

Catalog Number :

FCMAB411F

Subcategory :

Stem Cell Research

Product Name :

Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P21275

Host Name :

Mouse

Antigen :

Bone Morphogenetic Protein 4-FITC

Clone :

3H2

Conjugate :

FITC

Isotype :

IgG2b

Product Description :

Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

Cross Reactivity :

Human

Background :

Bone morphogenetic protein 4 (BMP4) is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.

ALT Names :

BMP-4;DVR-4

Immunogen :

Recombinant mouse BMP-4 (Masuhara, 1995).

Specificity :

Antibody recognizes BMP-4.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.