Milli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7 | EMD Millipore FCMAB410PE product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7

catalog :

FCMAB410PE

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

61-3E7

The same clone is also sold as:

LifeSpan Biosciences: LS-C180189
Santa Cruz Biotechnology: sc-33711

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Xie K, Liu Y, Hao W, Walter S, Penke B, Hartmann T, et al. Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice. Neurobiol Aging. 2013;34:2389-98 pubmed publisher
Prior M, Dargusch R, Ehren J, Chiruta C, Schubert D. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013;5:25 pubmed publisher
McHugh P, Wright J, Williams R, Brown D. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochem Int. 2012;61:672-80 pubmed publisher
Bihaqi S, Zawia N. Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr Alzheimer Res. 2012;9:555-62 pubmed
Zhao Y, Calon F, Julien C, Winkler J, Petasis N, Lukiw W, et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARÎ³-mediated mechanisms in Alzheimer's disease models. PLoS ONE. 2011;6:e15816 pubmed publisher

product information

Catalog Number :

FCMAB410PE

Subcategory :

Neuroscience

Product Name :

Milli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P56817

Host Name :

Mouse

Antigen :

BACE

Clone :

61-3E7

Conjugate :

Phycoerythrin

Isotype :

IgG1κ

Product Description :

Milli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7

Cross Reactivity :

Human

Background :

Alzheimer's disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid b-peptide (Ab). Ab generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Ab by b-secretase. The Ab peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. A human transmembrane aspartic-protease (Asp2), referred to as BACE, has been characterized and shown to have all the properties of b-secretase. Four groups in all have now confirmed that BACE (or Asp2) is a convincing candidate for b-secretase. BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational proteolytic cleavages and glycosylation. Sequence analysis has revealed that the immature form of BACE contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form by a signal peptidase located in the endoplasmic reticulum (ER), yielding the proBACE protein (Mr=75 kDa) which starts at residue 22. The proBACE protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE protein.

ALT Names :

Aspartyl protease 2;ASP2;Asp 2;Beta-site amyloid precursor protein cleaving enzyme 1;Beta-site APP cleaving enzyme 1;Memapsin-2;Membrane-associated aspartic protease 2

Immunogen :

Synthetic peptide corresponding to C-terminus of Human BACE.

Specificity :

Antibody recognizes human BACE (beta-site APP cleaving enzyme).

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.