Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33 | EMD Millipore FCMAB404PE product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33

catalog :

FCMAB404PE

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

Ab33

The same clone is also sold as:

Cell Signaling Technology: 4224

reactivity :

human

application :

flow cytometry

citations: 4

Reference
Leow C, Coffman K, Inigo I, Breen S, Czapiga M, Soukharev S, et al. MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models. Int J Oncol. 2012;40:1321-30 pubmed publisher
Makinde T, Agrawal D. Increased expression of angiopoietins and Tie2 in the lungs of chronic asthmatic mice. Am J Respir Cell Mol Biol. 2011;44:384-93 pubmed publisher
Dallabrida S, Ismail N, Pravda E, Parodi E, Dickie R, Durand E, et al. Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. FASEB J. 2008;22:3010-23 pubmed publisher
Parikh S, Mammoto T, Schultz A, Yuan H, Christiani D, Karumanchi S, et al. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006;3:e46 pubmed

product information

Catalog Number :

FCMAB404PE

Subcategory :

Cell Signaling

Product Name :

Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q02763

Host Name :

Mouse

Antigen :

Tie2/TEK-PE

Clone :

Ab33

Conjugate :

Phycoerythrin

Isotype :

IgG1κ

Product Description :

Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33

Cross Reactivity :

Human

Background :

TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.

ALT Names :

Tunica interna endothelial cell kinase;Tyrosine-protein kinase receptor TEK;Tyrosine-protein kinase receptor TIE-2;hTIE2;p140 TEK;CD202b

Immunogen :

Fusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells.

Specificity :

Antibody recognizes Human Tie2/TEK.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.