Milli-Mark™ Anti-IGF-I-Alexa Fluor® 488 Antibody, clone Sm1.2 | EMD Millipore FCMAB381A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-IGF-I-Alexa Fluor® 488 Antibody, clone Sm1.2

catalog :

FCMAB381A4

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

Sm1.2

The same clone is also sold as:

LifeSpan Biosciences: LS-C85204

reactivity :

human, mouse

application :

flow cytometry

citations: 3

Reference
Lu R, Wang Q, Han Y, Li J, Yang X, Miao D. Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. PLoS ONE. 2014;9:e93864 pubmed publisher
Chiu I, Chen A, Zheng Y, Kosaras B, Tsiftsoglou S, Vartanian T, et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008;105:17913-8 pubmed publisher
Shimizu M, Deguchi A, Hara Y, Moriwaki H, Weinstein I. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem Biophys Res Commun. 2005;334:947-53 pubmed

product information

Catalog Number :

FCMAB381A4

Subcategory :

Cell Signaling

Product Name :

Milli-Mark™ Anti-IGF-I-Alexa Fluor® 488 Antibody, clone Sm1.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05019

Host Name :

Mouse

Antigen :

IGF-I-Alexa Fluor® 488

Clone :

Sm1.2

Conjugate :

AlexaFluor®488

Isotype :

IgG1κ

Product Description :

Milli-Mark™ Anti-IGF-I-Alexa Fluor® 488 Antibody, clone Sm1.2

Cross Reactivity :

Human

Background :

Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5b. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues. The signal is transduced by intracellular events. IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

ALT Names :

Mechano growth factor;insulin-like growth factor 1;insulin-like growth factor 1 (somatomedin C): somatomedin C

Immunogen :

Human insulin-like growth factor I (IGF-I) purified from human plasma.

Specificity :

Antibody recognizes IGF-I

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.