Milli-Mark™ Anti-Integrin β1-Alexa Fluor® 488 Antibody, clone P5D2 | EMD Millipore FCMAB375A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-Integrin β1-Alexa Fluor® 488 Antibody, clone P5D2

catalog :

FCMAB375A4

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

P5D2

The same clone is also sold as:

R&D Systems: MAB17781, FAB17781P
Developmental Studies Hybridoma Bank: P5D2
Santa Cruz Biotechnology: sc-13590 L, sc-13590
Abcam: ab24693
BioLegend: 921304, 921303

reactivity :

human

application :

flow cytometry

citations: 25

Reference
Rui X, Mehrbod M, Van Agthoven J, Anand S, Xiong J, Mofrad M, et al. The ?-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in ?3 integrins. J Biol Chem. 2014;289:23256-63 pubmed publisher
Lee S, Kim J, Cho S, Kim H, Shin H, Jeon J, et al. TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling. Biochem J. 2014;459:565-76 pubmed publisher
O Brien X, Loosley A, Oakley K, Tang J, Reichner J. Technical advance: introducing a novel metric, directionality time, to quantify human neutrophil chemotaxis as a function of matrix composition and stiffness. J Leukoc Biol. 2014;95:993-1004 pubmed publisher
Karki R, Kim S, Kim D. Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res. 2013;319:3238-50 pubmed publisher
Iwai L, Payne L, Luczynski M, Chang F, Xu H, Clinton R, et al. Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. Biochem J. 2013;454:501-13 pubmed publisher
Blockhuys S, Van Rompaye B, De Rycke R, Lambein K, Claes K, Bracke M, et al. Radiation-induced myosin IIA expression stimulates collagen type I matrix reorganization. Radiother Oncol. 2013;108:162-7 pubmed publisher
Rapraeger A, Ell B, Roy M, Li X, Morrison O, Thomas G, et al. Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between ?V?3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesi. FEBS J. 2013;280:2194-206 pubmed publisher
Xu H, Bihan D, Chang F, Huang P, Farndale R, Leitinger B. Discoidin domain receptors promote Î±1Î²1- and Î±2Î²1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PLoS ONE. 2012;7:e52209 pubmed publisher
Vial D, McKeown Longo P. Epidermal growth factor (EGF) regulates ?5?1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A. J Biol Chem. 2012;287:40371-80 pubmed publisher
Fennewald S, Kantara C, Sastry S, Resto V. Laminin interactions with head and neck cancer cells under low fluid shear conditions lead to integrin activation and binding. J Biol Chem. 2012;287:21058-66 pubmed publisher
Steinberg F, Heesom K, Bass M, Cullen P. SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. J Cell Biol. 2012;197:219-30 pubmed publisher
Nummela P, Lammi J, Soikkeli J, Saksela O, Laakkonen P, Hölttä E. Transforming growth factor beta-induced (TGFBI) is an anti-adhesive protein regulating the invasive growth of melanoma cells. Am J Pathol. 2012;180:1663-74 pubmed publisher
Kimura H, Tome Y, Momiyama M, Hayashi K, Tsuchiya H, Bouvet M, et al. Imaging the inhibition by anti-?1 integrin antibody of lung seeding of single osteosarcoma cells in live mice. Int J Cancer. 2012;131:2027-33 pubmed publisher
Haseley A, Boone S, Wojton J, Yu L, Yoo J, Yu J, et al. Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res. 2012;72:1353-62 pubmed publisher
Sakai K, Nakamura T, Suzuki Y, Imizu T, Matsumoto K. 3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin ?1 function and matrix stiffness. Biochem Biophys Res Commun. 2011;412:98-103 pubmed publisher
Shannon Lowe C, Rowe M. Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection. PLoS Pathog. 2011;7:e1001338 pubmed publisher
Grzesiak J, Tran Cao H, Burton D, Kaushal S, Vargas F, Clopton P, et al. Knockdown of the ?(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer. 2011;129:2905-15 pubmed publisher
Starke R, Ferraro F, Paschalaki K, Dryden N, McKinnon T, Sutton R, et al. Endothelial von Willebrand factor regulates angiogenesis. Blood. 2011;117:1071-80 pubmed publisher
Xia B, Joubert A, Groves B, Vo K, Ashraf D, Djavaherian D, et al. Modulation of cell adhesion and migration by the histone methyltransferase subunit mDpy-30 and its interacting proteins. PLoS ONE. 2010;5:e11771 pubmed publisher
Ismail N, Pravda E, Li D, Shih S, Dallabrida S. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol. 2010;130:1307-17 pubmed publisher
Schneider I, Hays C, Waterman C. Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion. Mol Biol Cell. 2009;20:3155-67 pubmed publisher
Ksiazek K, Mikula Pietrasik J, Korybalska K, Dworacki G, Jorres A, Witowski J. Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin. Am J Pathol. 2009;174:1230-40 pubmed publisher
Degen M, Brellier F, Kain R, Ruiz C, Terracciano L, Orend G, et al. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. Cancer Res. 2007;67:9169-79 pubmed
Nolz J, Medeiros R, Mitchell J, Zhu P, Freedman B, Shimizu Y, et al. WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol. 2007;27:5986-6000 pubmed
Yahiro K, Morinaga N, Satoh M, Matsuura G, Tomonaga T, Nomura F, et al. Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin. Mol Microbiol. 2006;62:480-90 pubmed

product information

Catalog Number :

FCMAB375A4

Subcategory :

Cell Structure

Product Name :

Milli-Mark™ Anti-Integrin β1-Alexa Fluor® 488 Antibody, clone P5D2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05556

Host Name :

Mouse

Antigen :

Integrin β1-Alexa Fluor® 488

Clone :

P5D2

Conjugate :

AlexaFluor®488

Isotype :

IgG1

Product Description :

Milli-Mark™ Anti-Integrin β1-Alexa Fluor® 488 Antibody, clone P5D2

Cross Reactivity :

Human

Background :

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

ALT Names :

CD29

Immunogen :

Human keratinocytes derived from skin.

Specificity :

Reacts with Human Integrin Beta 1.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.