Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3 | EMD Millipore FCMAB343F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

catalog :

FCMAB343F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

ASC-3

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Kikkawa Y, Ogawa T, Sudo R, Yamada Y, Katagiri F, Hozumi K, et al. The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein. J Biol Chem. 2013;288:30990-1001 pubmed publisher
Fennewald S, Kantara C, Sastry S, Resto V. Laminin interactions with head and neck cancer cells under low fluid shear conditions lead to integrin activation and binding. J Biol Chem. 2012;287:21058-66 pubmed publisher
Zhang H, Guo F, Zhu G. Involvement of host cell integrin ?2 in Cryptosporidium parvum infection. Infect Immun. 2012;80:1753-8 pubmed publisher
Abolghait S, Iida T, Kodama T, Cantarelli V, Akeda Y, Honda T. Recombinant AexU effector protein of Aeromonas veronii bv. sobria disrupts the actin cytoskeleton by downregulation of Rac1 and induces direct cytotoxicity to ?4-integrin expressing cell lines. Microb Pathog. 2011;51:454-65 pubmed publisher
Grzesiak J, Tran Cao H, Burton D, Kaushal S, Vargas F, Clopton P, et al. Knockdown of the ?(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer. 2011;129:2905-15 pubmed publisher

product information

Catalog Number :

FCMAB343F

Subcategory :

Cell Structure

Product Name :

Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16144

Host Name :

Mouse

Antigen :

Integrin β4-FITC

Clone :

ASC-3

Conjugate :

FITC

Isotype :

IgG1κ

Product Description :

Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

Cross Reactivity :

Human

Background :

Integrin beta 4 is a glycoprotein which associates with the alpha 6 integrin to form the alpha 6/beta 4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

ALT Names :

Integrin beta-4;GP150;CD104

Immunogen :

Human Squamous Cell Carcinoma Cells (SCC 9)

Specificity :

Antibody recognizes Integrin β4.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.