| Reference |
|---|
Cheng J, Craft R, Yu G, Ho K, Wang X, Mohan G, et al. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS ONE. 2014;9:e115765 pubmed publisher |
Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed publisher |
Vorobyeva A, Lee R, Miller S, Longen C, Sharoni M, Kandelwal P, et al. Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation. J Biol Chem. 2014;289:33258-74 pubmed publisher |
Fernandez M, Klutkowski J, Freret T, Wolfe M. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. J Biol Chem. 2014;289:31043-52 pubmed publisher |
Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet. 2015;24:371-82 pubmed publisher |
Weitz T, Gate D, Rezai Zadeh K, Town T. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. Am J Pathol. 2014;184:2855-61 pubmed publisher |
Jung C, Uhm K, Horike H, Kim M, Misumi S, Ishida A, et al. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase. J Alzheimers Dis. 2015;43:1215-28 pubmed publisher |
Brunn A, Mihelcic M, Carstov M, Hummel L, Geier F, Schmidt A, et al. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol. 2014;184:2627-40 pubmed publisher |
Lin Y, Wang J, Wang K, Liao J, Cheng I. Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-? production. J Neurochem. 2014;131:407-12 pubmed publisher |
Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, et al. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J Neuroinflammation. 2014;11:124 pubmed publisher |
Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher |
Walberer M, Jantzen S, Backes H, Rueger M, Keuters M, Neumaier B, et al. In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain Res. 2014;1581:80-8 pubmed publisher |
Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed publisher |
Sullivan S, Dillon G, Sullivan J, Ho A. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid ? generation. J Biol Chem. 2014;289:15374-83 pubmed publisher |
Trazzi S, Fuchs C, De Franceschi M, Mitrugno V, Bartesaghi R, Ciani E. APP-dependent alteration of GSK3? activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2014;67:24-36 pubmed publisher |
Rodrigues D, Gutierres J, Pliássova A, Oliveira C, Cunha R, Agostinho P. Synaptic and sub-synaptic localization of amyloid-? protein precursor in the rat hippocampus. J Alzheimers Dis. 2014;40:981-92 pubmed publisher |
Del Campo M, Hoozemans J, Dekkers L, Rozemuller A, Korth C, Müller Schiffmann A, et al. BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease. Neurobiol Aging. 2014;35:1596-604 pubmed publisher |
Liu F, Liu T, Kung F. FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. J Biosci. 2014;39:85-95 pubmed |
Atkin G, Hunt J, Minakawa E, Sharkey L, Tipper N, Tennant W, et al. F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. J Biol Chem. 2014;289:7038-48 pubmed publisher |
Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed publisher |
Kim J, Yoon J, Kim Y. HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. PLoS ONE. 2013;8:e77972 pubmed publisher |
Shao B, Xia Z, Xie Q, Ge X, Zhang W, Sun J, et al. Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice. CNS Neurosci Ther. 2014;20:165-71 pubmed publisher |
Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed publisher |
Sosa M, De Gasperi R, Paulino A, Pricop P, Shaughness M, Maudlin Jeronimo E, et al. Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury. Acta Neuropathol Commun. 2013;1:51 pubmed publisher |
Notter T, Knuesel I. Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients. Acta Neuropathol Commun. 2013;1:27 pubmed publisher |
Wang W, Mutka A, Zmrzljak U, Rozman D, Tanila H, Gylling H, et al. Amyloid precursor protein ?- and ?-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. FASEB J. 2014;28:849-60 pubmed publisher |
Lee I, Jung K, Kim I, Park K. Amyloid-? oligomers regulate the properties of human neural stem cells through GSK-3? signaling. Exp Mol Med. 2013;45:e60 pubmed publisher |
Luo Y, Johnsen R, Griffiths L, Needham M, Fabian V, Fletcher S, et al. Primary over-expression of A?PP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK-A?PP transgenic mouse. Int J Exp Pathol. 2013;94:418-25 pubmed publisher |
Puzzo D, Loreto C, Giunta S, Musumeci G, Frasca G, Podda M, et al. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiol Aging. 2014;35:520-31 pubmed publisher |
Nelson C, Sheng M. Gpr3 stimulates A? production via interactions with APP and ?-arrestin2. PLoS ONE. 2013;8:e74680 pubmed publisher |
Muresan V, Villegas C, Ladescu Muresan Z. Functional interaction between amyloid-? precursor protein and peripherin neurofilaments: a shared pathway leading to Alzheimer's disease and amyotrophic lateral sclerosis?. Neurodegener Dis. 2014;13:122-5 pubmed publisher |
Chua L, Lim M, Wong B. The Kunitz-protease inhibitor domain in amyloid precursor protein reduces cellular mitochondrial enzymes expression and function. Biochem Biophys Res Commun. 2013;437:642-7 pubmed publisher |
Shukla M, Quirion R, Ma W. Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice. Neuroscience. 2013;250:92-101 pubmed publisher |
Urano Y, Ochiai S, Noguchi N. Suppression of amyloid-? production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. FASEB J. 2013;27:4305-15 pubmed publisher |
Ordóñez Gutiérrez L, Torres J, Gavin R, Anton M, Arroba Espinosa A, Espinosa J, et al. Cellular prion protein modulates ?-amyloid deposition in aged APP/PS1 transgenic mice. Neurobiol Aging. 2013;34:2793-804 pubmed publisher |
Laßek M, Weingarten J, Einsfelder U, Brendel P, Müller U, Volknandt W. Amyloid precursor proteins are constituents of the presynaptic active zone. J Neurochem. 2013;127:48-56 pubmed publisher |
Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 2013;46:126-35 pubmed publisher |
Trazzi S, Fuchs C, Valli E, Perini G, Bartesaghi R, Ciani E. The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome. J Biol Chem. 2013;288:20817-29 pubmed publisher |
Viswanathan J, Haapasalo A, Kurkinen K, Natunen T, Mäkinen P, Bertram L, et al. Ubiquilin-1 modulates ?-secretase-mediated ?-site cleavage in neuronal cells. Biochemistry. 2013;52:3899-912 pubmed publisher |
Liu B, Frost J, Sun J, Fu H, Grimes S, Blackburn P, et al. MER5101, a novel A?1-15:DT conjugate vaccine, generates a robust anti-A? antibody response and attenuates A? pathology and cognitive deficits in APPswe/PS1?E9 transgenic mice. J Neurosci. 2013;33:7027-37 pubmed publisher |
Lim Y, Murray L, Lai M, Chen C. NeuroAiD® (MLC601) and amyloid precursor protein processing. Cerebrovasc Dis. 2013;35 Suppl 1:30-7 pubmed publisher |
Kuszczyk M, Sanchez S, Pankiewicz J, Kim J, Duszczyk M, Guridi M, et al. Blocking the interaction between apolipoprotein E and A? reduces intraneuronal accumulation of A? and inhibits synaptic degeneration. Am J Pathol. 2013;182:1750-68 pubmed publisher |
Brunn A, Utermohlen O, Mihelcic M, Sanchez Ruiz M, Carstov M, Blau T, et al. Differential effects of CXCR4-CXCL12- and CXCR7-CXCL12-mediated immune reactions on murine P0106-125 -induced experimental autoimmune neuritis. Neuropathol Appl Neurobiol. 2013;39:772-87 pubmed publisher |
Beckett T, Studzinski C, Keller J, Paul Murphy M, Niedowicz D. A ketogenic diet improves motor performance but does not affect ?-amyloid levels in a mouse model of Alzheimer's disease. Brain Res. 2013;1505:61-7 pubmed publisher |
Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J Immunol. 2013;190:2896-903 pubmed publisher |
Jelic V, Hagman G, Yamamoto N, Teranishi Y, Nishimura T, Winblad B, et al. Abnormal platelet amyloid-? protein precursor (A?PP) metabolism in Alzheimer's disease: identification and characterization of a new A?PP isoform as potential biomarker. J Alzheimers Dis. 2013;35:285-95 pubmed publisher |
Canepa E, Domenicotti C, Marengo B, Passalacqua M, Marinari U, Pronzato M, et al. Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-? precursor protein metabolism. IUBMB Life. 2013;65:127-33 pubmed publisher |
Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A. Statins reduce amyloid ?-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochem Res. 2013;38:589-600 pubmed publisher |
Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R. Insulin has multiple antiamyloidogenic effects on human neuronal cells. Endocrinology. 2013;154:375-87 pubmed publisher |
Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed publisher |
Wahler A, Beyer A, Keller I, Schnack C, von Einem B, Pröpper C, et al. Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1). Biochem J. 2013;450:333-43 pubmed publisher |
Lauritzen I, Pardossi Piquard R, Bauer C, Brigham E, Abraham J, Ranaldi S, et al. The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci. 2012;32:16243-1655a pubmed publisher |
Li J, Xue Z, Deng S, Luo X, Patrylo P, Rose G, et al. Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury. Neurotox Res. 2013;24:1-14 pubmed publisher |
Zhu L, Su M, Lucast L, Liu L, Netzer W, Gandy S, et al. Dynamin 1 regulates amyloid generation through modulation of BACE-1. PLoS ONE. 2012;7:e45033 pubmed |
Kim I, Carlson B, Heindel C, Kim H, Soderling S. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem. 2012;287:39263-74 pubmed publisher |
Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall G, et al. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2013;24:360-70 pubmed publisher |
Huang J, Ferrari C, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, et al. Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z. Am J Pathol. 2012;181:1518-23 pubmed publisher |
Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, et al. Ryanodine receptor blockade reduces amyloid-? load and memory impairments in Tg2576 mouse model of Alzheimer disease. J Neurosci. 2012;32:11820-34 pubmed |
Sutinen E, Pirttila T, Anderson G, Salminen A, Ojala J. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-? production in human neuron-like cells. J Neuroinflammation. 2012;9:199 pubmed |
Chen Y, Huang X, Zhang Y, Rockenstein E, Bu G, Golde T, et al. Alzheimer's ?-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of ?-amyloid. J Neurosci. 2012;32:11390-5 pubmed |
Lai A, McLaurin J. Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Biochim Biophys Acta. 2012;1822:1629-37 pubmed publisher |
Chaufty J, Sullivan S, Ho A. Intracellular amyloid precursor protein sorting and amyloid-? secretion are regulated by Src-mediated phosphorylation of Mint2. J Neurosci. 2012;32:9613-25 pubmed publisher |
Gil Bea F, Gerenu G, Aisa B, Kirazov L, Schliebs R, Ramirez M. Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. Neurobiol Dis. 2012;48:439-46 pubmed publisher |
Walls K, Coskun P, Gallegos Perez J, Zadourian N, Freude K, RASOOL S, et al. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012;287:30317-27 pubmed publisher |
Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, et al. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012;9:151 pubmed publisher |
Yang G, Yang M, Lim Y, Lu J, Wang T, Qi J, et al. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem. 2012;122:1010-22 pubmed publisher |
Okamoto M. Immunoreactivity of the amino-terminal portion of the amyloid-beta precursor protein in the nucleolus. Neurosci Lett. 2012;521:82-7 pubmed publisher |
Tamayev R, D ADAMIO L. Memory deficits of British dementia knock-in mice are prevented by A?-precursor protein haploinsufficiency. J Neurosci. 2012;32:5481-5 pubmed publisher |
Nguyen H, Sawmiller D, Wu Q, Maleski J, Chen M. Evidence supporting the role of calpain in the ?-processing of amyloid-? precursor protein. Biochem Biophys Res Commun. 2012;420:530-5 pubmed publisher |
Hansmann F, Pringproa K, Ulrich R, Sun Y, Herder V, Kreutzer M, et al. Highly malignant behavior of a murine oligodendrocyte precursor cell line following transplantation into the demyelinated and nondemyelinated central nervous system. Cell Transplant. 2012;21:1161-75 pubmed publisher |
Woehrer A, Laszlo L, Finsterer J, Stollberger C, Furtner J, Rinner W, et al. Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. Acta Neuropathol. 2012;124:583-91 pubmed publisher |
Houacine J, Bolmont T, Aeschbach L, Oulad Abdelghani M, Fraering P. Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's A? peptides. Neurobiol Aging. 2012;33:2704-14 pubmed publisher |
Venkataramani V, Thiele K, Behnes C, Wulf G, Thelen P, Opitz L, et al. Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells. Am J Pathol. 2012;180:1636-52 pubmed publisher |
Ho T, Vessey K, Cappai R, Dinet V, Mascarelli F, Ciccotosto G, et al. Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. PLoS ONE. 2012;7:e29892 pubmed publisher |
Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher |
Bihaqi S, Zawia N. Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr Alzheimer Res. 2012;9:555-62 pubmed |
Sadleir K, Vassar R. Cdk5 protein inhibition and A?42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease. J Biol Chem. 2012;287:7224-35 pubmed publisher |
Morales Corraliza J, Berger J, Mazzella M, Veeranna -, Neubert T, Ghiso J, et al. Calpastatin modulates APP processing in the brains of ?-amyloid depositing but not wild-type mice. Neurobiol Aging. 2012;33:1125.e9-18 pubmed publisher |
Guo Q, Li H, Gaddam S, Justice N, Robertson C, Zheng H. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem. 2012;287:2437-45 pubmed publisher |
Wirths O, Dins A, Bayer T. A?PP accumulation and/or intraneuronal amyloid-? accumulation? The 3xTg-AD mouse model revisited. J Alzheimers Dis. 2012;28:897-904 pubmed publisher |
Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, et al. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci. 2012;69:1353-75 pubmed publisher |
Cullen D, Browne K, Xu Y, Adeeb S, Wolf J, McCarron R, et al. Blast-induced color change in photonic crystals corresponds with brain pathology. J Neurotrauma. 2011;28:2307-18 pubmed publisher |
Tang Schomer M, Johnson V, Baas P, Stewart W, Smith D. Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury. Exp Neurol. 2012;233:364-72 pubmed publisher |
Thomas R, Lelos M, Good M, Kidd E. Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochem Biophys Res Commun. 2011;415:656-61 pubmed publisher |
Toly Ndour C, Lui G, Nunes M, Bruley Rosset M, Aucouturier P, Dorothee G. MHC-independent genetic factors control the magnitude of CD4+ T cell responses to amyloid-? peptide in mice through regulatory T cell-mediated inhibition. J Immunol. 2011;187:4492-500 pubmed publisher |
Devi L, Ohno M. Mitochondrial dysfunction and accumulation of the ?-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis. 2012;45:417-24 pubmed publisher |
Demars M, Bartholomew A, Strakova Z, Lazarov O. Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res Ther. 2011;2:36 pubmed publisher |
Matrone C, Barbagallo A, La Rosa L, Florenzano F, Ciotti M, Mercanti D, et al. APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci. 2011;31:11756-61 pubmed publisher |
Bailey J, Ray B, Greig N, Lahiri D. Rivastigmine lowers A? and increases sAPP? levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS ONE. 2011;6:e21954 pubmed publisher |
Griffiths H, Whitehouse I, Baybutt H, Brown D, Kellett K, Jackson C, et al. Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem. 2011;286:33489-500 pubmed publisher |
Cai Y, Zhang X, Macklin L, Cai H, Luo X, Oddo S, et al. BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology. Neurotox Res. 2012;21:160-74 pubmed publisher |
Freude K, Penjwini M, Davis J, LaFerla F, Blurton Jones M. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011;286:24264-74 pubmed publisher |
Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, et al. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. J Neurosci. 2011;31:6850-7 pubmed publisher |
Hao Y, Hao C, Perkinton M, Chan W, Chan H, Miller C, et al. GULP1 is a novel APP-interacting protein that alters APP processing. Biochem J. 2011;436:631-9 pubmed publisher |
Sarajärvi T, Tuusa J, Haapasalo A, Lackman J, Sormunen R, Helisalmi S, et al. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol. 2011;31:2326-40 pubmed publisher |
Upadhaya A, Lungrin I, Yamaguchi H, Fändrich M, Thal D. High-molecular weight A? oligomers and protofibrils are the predominant A? species in the native soluble protein fraction of the AD brain. J Cell Mol Med. 2012;16:287-95 pubmed publisher |
Nie H, Li Z, Yan Q, Wang Z, Zhao W, Guo L, et al. Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells. Neurochem Res. 2011;36:904-12 pubmed publisher |
Chigurupati S, Madan M, Okun E, Wei Z, Pattisapu J, Mughal M, et al. Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model. J Alzheimers Dis. 2011;24:349-61 pubmed publisher |
Thomas R, Liddell J, Kidd E. Anti-amyloid precursor protein immunoglobulins inhibit amyloid-? production by steric hindrance. FEBS J. 2011;278:167-78 pubmed publisher |
Bordji K, Becerril Ortega J, Nicole O, Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci. 2010;30:15927-42 pubmed publisher |
Tamayev R, Giliberto L, Li W, d Abramo C, Arancio O, Vidal R, et al. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci. 2010;30:14915-24 pubmed publisher |
Dinet V, An N, Ciccotosto G, Bruban J, Maoui A, Bellingham S, et al. APP involvement in retinogenesis of mice. Acta Neuropathol. 2011;121:351-63 pubmed publisher |
Jarvis C, Goncalves M, Clarke E, Dogruel M, Kalindjian S, Thomas S, et al. Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. Eur J Neurosci. 2010;32:1246-55 pubmed publisher |
Whitehouse I, Jackson C, Turner A, Hooper N. Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J Alzheimers Dis. 2010;22:1023-31 pubmed publisher |
Maarouf C, Daugs I, Kokjohn T, Kalback W, Patton R, Luehrs D, et al. The biochemical aftermath of anti-amyloid immunotherapy. Mol Neurodegener. 2010;5:39 pubmed publisher |
Devi L, Ohno M. Phospho-eIF2? level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS ONE. 2010;5:e12974 pubmed publisher |
Kern D, Maclean K, Jiang H, Synder E, Sladek J, Bjugstad K. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplant. 2011;20:371-9 pubmed publisher |
Pavlov P, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, et al. Mitochondrial ?-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2011;25:78-88 pubmed publisher |
Cai Y, Xiong K, Zhang X, Cai H, Luo X, Feng J, et al. ?-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ?-amyloid accumulation. Eur J Neurosci. 2010;32:1223-38 pubmed publisher |
Behbahani H, Pavlov P, Wiehager B, Nishimura T, Winblad B, Ankarcrona M. Association of Omi/HtrA2 with ?-secretase in mitochondria. Neurochem Int. 2010;57:668-75 pubmed publisher |
Gray E, De Vos K, Dingwall C, Perkinton M, Miller C. Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production. J Alzheimers Dis. 2010;21:1101-5 pubmed publisher |
Young Pearse T, Suth S, Luth E, Sawa A, Selkoe D. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci. 2010;30:10431-40 pubmed publisher |
Li Q, Wang H, Wang Z, Ma J, Ding J, Chen S. Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. Neurosci Lett. 2010;481:154-8 pubmed publisher |
Spain A, Daumas S, Lifshitz J, Rhodes J, Andrews P, Horsburgh K, et al. Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury. J Neurotrauma. 2010;27:1429-38 pubmed publisher |
Garcia P, Youssef I, Utvik J, Florent Béchard S, Barthélémy V, Malaplate Armand C, et al. Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease. J Neurosci. 2010;30:7516-27 pubmed publisher |
Ko S, Lin Y, Lin Y, Chang S. Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species. Free Radic Biol Med. 2010;49:474-80 pubmed publisher |
Gimbel D, Nygaard H, Coffey E, Gunther E, Lauren J, Gimbel Z, et al. Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci. 2010;30:6367-74 pubmed publisher |
Zhang X, Xiong K, Cai Y, Cai H, Luo X, Feng J, et al. Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex. Eur J Neurosci. 2010;31:710-21 pubmed publisher |
Chen A, Guo L, Ostaszewski B, Selkoe D, LaVoie M. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem. 2010;285:11378-91 pubmed publisher |
Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli I, Walter J, et al. Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem. 2010;285:10678-89 pubmed publisher |
Zhang X, Cai Y, Xiong K, Cai H, Luo X, Feng J, et al. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci. 2009;30:2271-83 pubmed publisher |
Frugier T, Morganti Kossmann M, O Reilly D, McLean C. In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury. J Neurotrauma. 2010;27:497-507 pubmed publisher |
Salameh M, Robinson J, Navaneetham D, Sinha D, Madden B, Walsh P, et al. The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. J Biol Chem. 2010;285:1939-49 pubmed publisher |
Walton J, Wang M. APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease. J Inorg Biochem. 2009;103:1548-54 pubmed publisher |
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, et al. Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. J Biol Chem. 2009;284:34433-43 pubmed publisher |
Ma T, Zhao Y, Kwak Y, Yang Z, Thompson R, Luo Z, et al. Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. J Neurosci. 2009;29:11226-36 pubmed publisher |
Ray B, Bailey J, Sarkar S, Lahiri D. Molecular and immunocytochemical characterization of primary neuronal cultures from adult rat brain: Differential expression of neuronal and glial protein markers. J Neurosci Methods. 2009;184:294-302 pubmed publisher |
Peng S, Garzon D, Marchese M, KLEIN W, Ginsberg S, Francis B, et al. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci. 2009;29:9321-9 pubmed publisher |
Choi J, Berger J, Mazzella M, Morales Corraliza J, Cataldo A, Nixon R, et al. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem. 2009;110:1818-27 pubmed publisher |
HOE H, Lee K, Carney R, Lee J, Markova A, Lee J, et al. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009;29:7459-73 pubmed publisher |
Wu F, Matsuoka Y, Mattson M, Yao P. The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide. Biochem Biophys Res Commun. 2009;385:247-50 pubmed publisher |
Rose J, Crews L, Rockenstein E, Adame A, Mante M, Hersh L, et al. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009;29:1115-25 pubmed publisher |
Matsuda S, Giliberto L, Matsuda Y, McGowan E, D ADAMIO L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008;28:8668-76 pubmed publisher |
Young Pearse T, Chen A, Chang R, Marquez C, Selkoe D. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008;3:15 pubmed publisher |
Lee Y, Tharp W, Maple R, Nair S, Permana P, Pratley R. Amyloid precursor protein expression is upregulated in adipocytes in obesity. Obesity (Silver Spring). 2008;16:1493-500 pubmed publisher |
Krause K, Karger S, Sheu S, Aigner T, Kursawe R, Gimm O, et al. Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol. 2008;198:291-9 pubmed publisher |
Rohn T, Vyas V, Hernandez Estrada T, Nichol K, Christie L, Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci. 2008;28:3051-9 pubmed publisher |
HOE H, Cooper M, Burns M, Lewis P, Van Der Brug M, Chakraborty G, et al. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. J Neurosci. 2007;27:10895-905 pubmed |
