Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4 | EMD Millipore FCMAB290F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

catalog :

FCMAB290F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

6C4

The same clone is also sold as:

Invitrogen: 32-0300
BD Biosciences: 556341
LifeSpan Biosciences: LS-C15366

reactivity :

human, rat

application :

flow cytometry

product information

Catalog Number :

FCMAB290F

Subcategory :

Neuroscience

Product Name :

Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P19491

Host Name :

Mouse

Antigen :

GluR2-FITC

Clone :

6C4

Conjugate :

FITC

Isotype :

IgG2aκ

Product Description :

Milli-Mark™ Anti-GluR2-FITC Antibody, clone 6C4

Cross Reactivity :

Human

Background :

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this positionis occupied by a Gln residue. In GluR2, it is occupied by an Arg residue. It has been shown experimentally that the presence of Arg in this position blocks CA2+ ion permeability, while a Gln does not. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.

ALT Names :

glutamate receptor 2

Immunogen :

Recombinant fusion protein TrpE-GluR2 (putative N-terminal portion, amino acids 175-430).

Specificity :

Antibody recognizes Glutamate Receptor 2.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.