Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11 | EMD Millipore FCMAB227F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11

catalog :

FCMAB227F

quantity :

100 tests

clonality :

monoclonal

host :

hamsters

conjugate :

FITC

clone name :

145-2C11

The same clone is also sold as:

Invitrogen: 36-0031-85, 48-0031-80, A14714, MA1-10187, 47-0031-82, 14-0031-82, 61-0031-82, 63-0031-82, 15-0031-83, 25-0031-82, 62-0031-82, 12-0031-85, MA5-17655, 15-0031-81, 17-0031-63, 14-0031-86, 11-0031-86, 12-0031-81, 12-0031-83, MA1-10186, 16-0031-38, 16-0031-82, 13-0031-85, 25-0031-81, 35-0031-80, 45-0031-82, 15-0031-82, 17-0031-83, 16-0031-025, 53-0031-80, 16-0031-86, 11-0031-81, 47-0031-80, 61-0031-80, 14-0031-85, 78-0031-82, 17-0031-81, MA1-10184, 45-0031-80, 13-0031-82, 16-0031-050, 12-0031-82, 17-0031-82, 53-0031-82, MA1-84019, 13-0031-86, 35-0031-82, 11-0031-85, 48-0031-82, 11-0031-82, 16-0031-85, 13-0031-81, MA5-17656, 16-0031-81, MA5-17658
Miltenyi Biotec: 130-101-990, 130-102-793, 130-121-440, 130-102-794, 130-102-600, 130-092-973, 130-101-940, 130-102-549, 130-093-179, 130-102-496, 130-102-359, 130-102-792, 130-102-791
Novus Biologicals: NBP2-52693-0.2mg, NBP2-52641-0.2mg
R&D Systems: MAB484-100
OriGene: AM12132AC-N, TA320270, CL001PX, CL001, AM12132FC-N, CL001BX, CL001F, CL001P, AM12132LE-N, AM12132RP-N, AM12132PU-N, CL001A, CL001B, CL001FX
Rockland Immunochemicals: 200-B08-M69, 200-B02-M69
Bio X Cell: BE0001-1-5MG, BE0001-1-100MG, BP0001-1-50MG, BE0001-1-1MG, BP0001-1-5MG, BE0001-1-25MG, BP0001-1-100MG, BE0001-1-50MG, BP0001-1-25MG
Abnova: MAB12205, MAB5911, MAB15456, MAB9826, MAB5907, MAB5909, MAB3220, MAB15455, MAB15454
Emfret Analytics: 70-0031
Bio-Rad: MCA2690T, MCA2690GA, MCA2690A488, MCA2690
LifeSpan Biosciences: LS-C21526, LS-C148326, LS-C196284, LS-C122846, LS-C21527, LS-C112612, LS-C62561, LS-C357688, LS-C127316, LS-C112611, LS-C86802, LS-C195595, LS-C357652, LS-C148323, LS-C357689, LS-C357651, LS-C112613, LS-C62562, LS-C21522, LS-C196283, LS-C21523, LS-C34550, LS-C357691, LS-C21521, LS-C112430, LS-C45012, LS-C62819, LS-C105774
BioLegend: 100355, 100367, 100307, 100341, 100336, 100371, 100339, 100321, 100302, 100349, 100365, 100312, 100322, 100347, 100326, 100305, 100330, 100360, 100351, 100303, 100319, 100348, 100309, 100327, 100372, 100361, 100353, 100334, 100340, 100366, 100363, 100368, 100310, 100364, 100328, 100320, 100335, 100324, 100345, 100304, 100308, 100359, 100306, 100329, 100362, 100301, 100333, 100311, 100325
Tonbo Biosciences: 30-0031
Absolute Antibody: Ab00105-1.1, Ab00105-6.1, Ab00105-22.0, Ab00105-10.0, Ab00105-23.0, Ab00105-6.4, Ab00105-1.4
BD Biosciences: 552774, 553067, 562332, 557666, 561826, 557306, 557596, 561100, 561827, 561108, 553057, 553058, 553059, 553063, 563565, 562286, 561825, 562600, 553061, 553064, 550275, 561042, 561089, 553060, 551163, 553066, 553065, 553062, 561824
Exbio: T9-578-C025, 11-578-C100, 1A-578-C025, T9-578-C100, 12-578-C100, 1A-578-C100, 1P-578-C100, PC-578-C025, T7-578-C025, 1P-578-C025, 1B-578-C100, PC-578-C100, 11-578-C025, T7-578-C100, 1F-578-C100
MilliporeSigma: SAB4700555, SAB4700553
Santa Cruz Biotechnology: sc-18871, sc-18871 L

reactivity :

mouse

application :

flow cytometry

citations: 4

Reference
Licata L, Nguyen C, Burga R, Falanga V, Espat N, Ayala A, et al. Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils. J Leukoc Biol. 2013;94:813-23 pubmed publisher
San Luis B, Sondgeroth B, Nassar N, Carpino N. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. J Biol Chem. 2011;286:15943-54 pubmed publisher
Boding L, Nielsen M, Bonefeld C, von Essen M, Nielsen B, Lauritsen J, et al. Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation. Mol Immunol. 2010;47:2450-7 pubmed publisher
Carpino N, Chen Y, Nassar N, Oh H. The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways. Mol Immunol. 2009;46:3224-31 pubmed publisher

product information

Catalog Number :

FCMAB227F

Subcategory :

Inflammation & Immunology

Product Name :

Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P22646

Host Name :

Hamster

Antigen :

mouse CD3-FITC

Clone :

145-2C11

Conjugate :

FITC

Isotype :

IgG

Product Description :

Milli-Mark™ Anti-mouse CD3-FITC Antibody, clone 145-2C11

Cross Reactivity :

Mouse

Background :

Human TCR/CD3 is a complex structure on the lymphocyte surface. It consists of the TCR alpha beta or TCR gamma delta heterodimer and the associated CD3 complex. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon. and zeta. Three different dimers, gamma epsilon, delta epsilon, and zeta zeta, constitute the CD3 complex. The MW of CD3epsilon is 20 000 (Campana, 1987). CD3 is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface (Swerdlow, 1988; Beverley, 1981). The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies (McMichael, 1987). Consistent with the pattern of synthesis of the antigen in normal thymocytes, the earliest site detectable within neoplastic cells is the cell cytoplasm (Swerdlow, 1988).

ALT Names :

T-cell surface glycoprotein CD3 epsilon chain;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e

Immunogen :

Animals were immunized with the BM10-37 mouse cytotoxic T lymphocyte (CTL) cell clone (anti H-2 Kb). Spleen cells were fused with Sp2/0-Ag14 myeloma cells.

Specificity :

Antibody recognizes CD3 epsilon chain.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.