Milli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7 | EMD Millipore FCMAB224F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7

catalog :

FCMAB224F

quantity :

100 tests

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

E13 161-7

The same clone is also sold as:

Abcam: ab51317

reactivity :

mouse

application :

flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Petrakova O, Terskikh V, Chernioglo E, Ashapkin V, Bragin E, Shtratnikova V, et al. Comparative analysis reveals similarities between cultured submandibular salivary gland cells and liver progenitor cells. Springerplus. 2014;3:183 pubmed publisher

product information

Catalog Number :

FCMAB224F

Subcategory :

Stem Cell Research

Product Name :

Milli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05533

Host Name :

Rat

Antigen :

Sca-1-FITC

Clone :

E13 161-7

Conjugate :

FITC

Isotype :

IgG2aκ

Product Description :

Milli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7

Cross Reactivity :

Mouse

Background :

Stem cell antigen-1, or Sca-1, is a murine cell surface antigen which is also called Ly6A/E or Ly6D. Sca-1 is essential for HSC differentiation. Once initial differentiation occurs, Sca-1 presence on the cell surface will continue to further influence differentiation; as is seen in skeletal muscle cells that have formed from HSC and which further differentiate into neural and endothelial cells. As such, the identification and characterization of these differentiation cascades might enhance clinical disease therapy by enhancing understanding of the way that Sca-1 is involved in HSC homing and migration. There is evidence to suggest that bone marrow stem cells are signaled by the injured tissue for release into the circulation where they differentiate and proceed to the problem area. Additionally, evidence suggests that aggressive breast cancer tumors express higher levels of Sca-1; that expression of this stem cell marker is up-regulated in cancer. A problem with the migration mechanisms influenced by Sca-1 might result in a prolonged diseased state. The gene encoding this antigen has been cloned independently as TAP (T-cell activating protein) by Reiser et al. (1988), who referred to the encoded protein as Ly6.2. The antigen is expressed on immature hematopoietic progenitor cells and, together with other markers, defines hematopoietic stem cells. Antibodies directed against Sca-1 are used to fractionate early hematopoietic progenitor cells that have the ability to repopulate bone marrow in vivo and are thus considered to represent very early forms of murine hematopoietic stem cells.

ALT Names :

Lymphocyte antigen 6A-2/6E-1;Ly-6A.2/Ly-6E.1;Stem cell antigen 1;T-cell-activating protein;TAP

Immunogen :

Mouse Pre-T cell hybridoma

Specificity :

Antibody recognizes stem cell antigen-1 (Sca-1).

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.