This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2
catalog :
FCMAB214P
quantity :
100 tests
clonality :
monoclonal
host :
mouse
conjugate :
PE
reactivity :
human
application :
flow cytometry
citations: 2
Reference
Wickham A, Islam M, Mondal D, Phopase J, Sadhu V, Tamás E, et al. Polycaprolactone-thiophene-conjugated carbon nanotube meshes as scaffolds for cardiac progenitor cells. J Biomed Mater Res B Appl Biomater. 2014;102:1553-61 pubmed publisher
Janson C, Kasahara N, Prendergast G, Colicelli J. RIN3 is a negative regulator of mast cell responses to SCF. PLoS ONE. 2012;7:e49615 pubmed publisher
product information
Catalog Number :
FCMAB214P
Subcategory :
Inflammation & Immunology
Product Name :
Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P10721
Host Name :
Mouse
Antigen :
CD117
Clone :
104D2
Conjugate :
Phycoerythrin
Isotype :
IgG1κ
Product Description :
Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2
Cross Reactivity :
Human
Background :
CD117 is a 145 kDa transmembrane protein which belongs to the class III receptor tyrosine kinase family. The extracellular region consists of five immunoglobulin-like domains where the second and third loops are thought to be involved in ligand binding (Ashman, 1997; Bühring, 1995). CD117 has been shown to be a marker for tissue mast cells, hematopoietic stem cells, and progenitor cells in normal human bone marrow. The majority of CD117-positive marrow cells (50-70%) co-express CD34 and comprise progenitor cells and their precursors of all hematopoietic lineages. Apart from mast cells, CD117 is essentially absent from mature hematopoietic cells. Although CD117 is primarily a marker for non-lymphoid progenitor cells in the hematopoietic cells/tissues, including melanocytes, embryonic brain, and the reproductive system (Ashman, 1997). Anti-CD117, 104D2, was included in the Sixth International Workshop and Conference on Human Leucocyte differentiation Antigens, and studies by different laboratories confirmed its reactivity with CD117 (Ashman, 1997).
ALT Names :
Mast/stem cell growth factor receptor;SCFR;Tyrosine-protein kinase Kit;Proto-oncogene c-Kit
Immunogen :
MOLM-1 megakaryocytic cell line.
Specificity :
Antibody recognizes Human CD117 antigen.
Package Size :
100 tests
Uses :
Flow Cytometry
Storage :
Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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