Milli-Mark™ Anti-CD33-FITC Antibody, clone WM-54 | EMD Millipore FCMAB193F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-CD33-FITC Antibody, clone WM-54

catalog :

FCMAB193F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

WM-54

The same clone is also sold as:

Invitrogen: MA1-90498

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

FCMAB193F

Subcategory :

Inflammation & Immunology

Product Name :

Milli-Mark™ Anti-CD33-FITC Antibody, clone WM-54

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P20138

Host Name :

Mouse

Antigen :

CD33-FITC

Clone :

WM-54

Conjugate :

FITC

Isotype :

IgG1κ

Product Description :

Milli-Mark™ Anti-CD33-FITC Antibody, clone WM-54

Cross Reactivity :

Human

Background :

CD33 is a member of the siglec family (sialic acid binding immunoglobulin-like lectins) referred to as Siglec-3 (Freeman SD, Kelm S, Barber EK and Crocker PR, 1995, Blood, 2005-2012). It is the smallest member of the siglec family having a molecular weight of 67 kDa (Peiper SC, Ashmun RA and Look TA (1988) Blood., 72: 314-321). CD33 mediates protein-carbohydrate cellular interactions in addition to protein-protein recognition (Crocker, 2002). The CD33 gene is located on chromosome 19 (Peiper, 1997). CD33 is expressed by subsets of monocytes and neutrophils. CD33 is the major antigen to differentially diagnose myeloid from lymphoid leukemias, as it is expressed on 90% of myeloid and not lymphoid leukemic cells (Andrews 1989; Griffin 1984; and Sabbath 1986). Committed hemapoietic progenitors, including multipotential stem cells (CFU-GEMM) and precursors of granulocytes and macrophages (CFU-GM) and early erythroid progenitors (BFU-E) express CD33 (Peiper, 1989 and 1997). Anti-CD33, WM-54, was included in the Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD33 (Peiper, 1989).

ALT Names :

Myeloid cell surface antigen CD33;Sialic acid-binding Ig-like lectin 3;Siglec-3;gp67

Immunogen :

Leukemic cells from a patient with AML.

Specificity :

Antibody recognizes Human CD33 antigen.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.