Milli-Mark Anti-CD3 -PECy5 Antibody, clone UCHT1 | EMD Millipore FCMAB169C5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark Anti-CD3 -PECy5 Antibody, clone UCHT1

catalog :

FCMAB169C5

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

PE-Cy5

clone name :

UCHT1

The same clone is also sold as:

Abcam: ab22
Invitrogen: MA1-80044, 606-0038-42, 11-0038-41, 11-0038-42, 64-0038-41, MA1-10177, 58-0038-41, A15440, CD0328, 16-0038-85, 13-0038-80, MA1-80537, 12-0038-41, 63-0038-42, 58-0038-42, MA1-21454, 69-0038-41, 505-0038-42, 61-0038-42, MA1-10178, 16-0038-050, 25-0038-41, 48-0038-82, 47-0038-42, CD0326, 16-0038-025, 14-0038-82, 48-0038-41, 17-0038-42, 64-0038-42, GM4013-5, 11-0038-80, 15-0038-41, 15-0038-42, 606-0038-41, 17-0038-41, 16-0038-81, 48-0038-42, 14-0038-80, 12-0038-42, MA1-10181, 62-0038-41, CD0330TR, Q10054, 56-0038-80, CD0304, 505-0038-41, A51001, 69-0038-42, CD0329, 47-0038-41, 56-0038-82, 56-0038-42, 67-0038-42, 78-0038-42, CD0330, 16-0038-38, CD0301, 13-0038-82, 62-0038-42, 25-0038-42, CD0305, MA1-10179
Abnova: MAB9817, MAB6007, MAB4402, MAB6009, MAB6008, MAB6010, MAB6006, MAB6004, MAB9816

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Yurugi H, Tanida S, Akita K, Ishida A, Toda M, Nakada H. Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation. Biochem Biophys Res Commun. 2013;434:376-81 pubmed publisher
Teigler J, Iampietro M, Barouch D. Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys. J Virol. 2012;86:9590-8 pubmed publisher
Yurugi H, Tanida S, Ishida A, Akita K, Toda M, Inoue M, et al. Expression of prohibitins on the surface of activated T cells. Biochem Biophys Res Commun. 2012;420:275-80 pubmed publisher
Nikolic D, Lehmann M, Felts R, Garcia E, Blanchet F, Subramaniam S, et al. HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation. Blood. 2011;118:4841-52 pubmed publisher
Mei H, Frölich D, Giesecke C, Loddenkemper C, Reiter K, Schmidt S, et al. Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab. Blood. 2010;116:5181-90 pubmed publisher
Darke C, Coates E. One-tube HLA-B27/B2708 typing by flow cytometry using two "Anti-HLA-B27" monoclonal antibody reagents. Cytometry B Clin Cytom. 2010;78:21-30 pubmed publisher
Woo J, Liu J, Kang S, Singh R, Park S, Su Y, et al. GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1) for phase I/II clinical trials. Protein Expr Purif. 2008;58:1-11 pubmed

product information

Catalog Number :

FCMAB169C5

Subcategory :

Inflammation & Immunology

Product Name :

Milli-Mark Anti-CD3 -PECy5 Antibody, clone UCHT1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P20963

Host Name :

Mouse

Antigen :

CD3 -PECy5

Clone :

UCHT1

Conjugate :

Phycoerythrin/Cy5

Isotype :

IgG1κ

Product Description :

Milli-Mark Anti-CD3 -PECy5 Antibody, clone UCHT1

Cross Reactivity :

Human

Background :

Human TCR/CD3 is a complex structure on the lymphocyte surface. It consists of the TCR alpha beta or TCR gamma delta heterodimer and the associated CD3 complex. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon. and zeta. Three different dimers, gamma epsilon, delta epsilon, and zeta zeta, constitute the CD3 complex. The MW of CD3epsilon is 20 000 (Campana, 1987). CD3 is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface (Swerdlow, 1988; Beverley, 1981). The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies (McMichael, 1987). Consistent with the pattern of synthesis of the antigen in normal thymocytes, the earliest site detectable within neoplastic cells is the cell cytoplasm (Swerdlow, 1988).

ALT Names :

T-cell receptor

Immunogen :

Human infant thymocytes and lymphocytes from a patient with Sézary disease.

Specificity :

Antibody recognizes Human CD3 antigen.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.