Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46 | EMD Millipore FCMAB143F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46

catalog :

FCMAB143F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

RPA20, 1-46

reactivity :

human, mouse

application :

flow cytometry

product information

Catalog Number :

FCMAB143F

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P15927

Host Name :

Mouse

Antigen :

RPA2 p34 -FITC

Clone :

RPA20, 1-46

Conjugate :

FITC

Isotype :

IgG1κ

Product Description :

Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46

Cross Reactivity :

Human

Background :

RPA is a heterotrimeric protein complex that binds specifically to single-stranded DNA (ssDNA). It is composed of three subunits, RPA1 (70 kDa), RPA2 (32 kDa), and RPA3 (14 kDa), and plays multiple roles in DNA metabolism. RPA is required for DNA replication initiation, as well as replication elongation. At the onset of DNA replication, RPA is loaded onto chromatin after the binding of Cdc45 to origins. RPA is needed for subsequent loading of DNA polymerase and other replication proteins to initiate DNA replication. After DNA replication begins, RPA moves with replication forks, stabilizing ssDNA and assisting in DNA synthesis. In addition to its replication function, RPA is also known to play essential roles in damage repair and recombination.The 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK. Alternate names for RPA32 include replication protein A 32 kDa subunit, RP-A, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, and RPA32.

ALT Names :

RF-A protein 2 RP-A p32 RP-A p34 Replication factor A protein 2 replication protein A2 (32kD) replication protein A2, 32kDa Replication protein A 32kDa subunit RF-A, replication factor-A protein 2 p32 p34 RPA2 REPA2 RPA32.

Immunogen :

His-tagged recombinant protein corresponding to human RPA2

Specificity :

Antibody recognizes RPA2

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.