Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate | EMD Millipore FCMAB122F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

catalog :

FCMAB122F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

6E4

reactivity :

human, mouse

application :

flow cytometry

product information

Catalog Number :

FCMAB122F

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P45983

Host Name :

Mouse

Antigen :

c-Jun

Clone :

6E4

Conjugate :

FITC

Isotype :

IgG1κ

Product Description :

Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

Cross Reactivity :

Human;Mouse;Rat

Background :

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.

ALT Names :

JNK1 alpha protein kinase JNK1 beta protein kinase JUN N-terminal kinase Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1 mitogen-activated protein kinase 8 mitogen-activated protein kinase 8 isoform JNK1 alpha1 mitogen-activated protein kinase 8 isoform JNK1 beta2 protein kinase JNK1

Immunogen :

GST-tagged recombinant protein corresponding to c-Jun.

Specificity :

Antibody recognizes c-Jun.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.